Li-钙黏蛋白在结直肠癌及腺瘤中表达的相关研究

Associated Study on the Li-cadherin Expression in Colorectal Carcinoma and Adenoma

目的:探讨Li-钙黏蛋白(Li-cad)在结直肠腺癌及腺瘤发生、发展及其生物学行为中的作用。方法:对60例结直肠腺癌、60例结直肠绒毛状腺瘤、60例结直肠管状腺瘤及60例正常结直肠黏膜标本采用免疫组化Sp法检测Li-cad的表达水平。结果:(1)结直肠癌组Li-cad表达阳性率明显低于绒毛状腺瘤、管状腺瘤及正常对照组(均P<0.05);绒毛状腺瘤组Li-cad表达阳性率低于管状腺瘤和正常对照组(均P<0.05);但管状腺瘤组Li-cad的表达阳性率与正常对照组差别无统计学意义(P>0.05)。(2)管状腺瘤组及绒毛状腺瘤组均表现为不典型增生程度越重,Li-cad表达阳性率越低(均P<0.01)。(3)Li-cad表达阳性率与肿瘤分化程度、淋巴结转移及TNM分期相关,与性别、年龄、肿瘤部位无关。结论:Li-钙黏蛋白在结直肠腺癌的发生中起一定作用并与其恶性程度及转移有关。

Objective： To evaluate the role of Li-cadherin on growth, progress and biology behavior in colorectal carcinoma and adenoma. Methods： The expressions of Li-cadherin were detected by immuno-histochemical Sp method in 60 patients with colorectal carcinoma, 60 with villous adenoma, 60 with tubular adenoma and 60 normal controls. Results： （1）The expression of Li-cadherin in colorectal carcinoma was the lowest among all groups, and there was a significant difference （P 〈 0.05）. The expression of Li-cadherin in villous adenoma was lower than tubularadenoma and normal control group, and there was a significant difference （P 〈 0.05）. But there was no difference between tubular adenoma and normal control group （P 〉 0.05）. （2） The higher the degree of atypical hyperplasia expression in tubularadenoma and villous adenoma groups were, the lower level the positive expression of Li-cadherin was（P 〈 0.01 ）. （3） The positive expression of Li-cadherin was statistically correlated with the degrees of tumor differentiation, lymph node metastasis and TNM staging. Li-cadherin expression was not significantly related to sex, age and location of tumor. Conclusion： Li-cadherin plays a role in colorectal carcinoma development and has a relationship with malignancy and metastasis of colorectal carcinoma.