多发性肌炎中药治疗的实验研究

Experimental Research of Polymyositis Animal Models Treated with Chinese Materia Medica

本文分别用柴胡、桂枝治疗病毒性多发性肌炎豚鼠(PM)模型,并与空白对照组进行了比较。比较了治疗前后的症状、肌酶谱和病理改变。结果表明柴胡组和桂枝组的炎症有明显的改善,而空白对照组有加重的表现(p<0.05)。显示了柴胡和桂枝对PM有良好的治疗效果。其抑制作用可能与它们对淋巴因子游离、IL-2(白介素Ⅱ)的产生和炎症反应的被抑制有关。

Viral polymyositis guinea pig models were treated with bupleurum chinense DC . and cinnamomum cassia presl respectively. The symptom, muscle enzyme spectrum and pathological changes in the models were compared with those in control group. The results showed that bupleurum chinense DC . and cinnamomum cassia presl had obvious therapeutic effect on polymyositis guinea pig models. The control group had an aggravating trend (p<0.05) . Their suppressive effect on cellular immunity were associated with their suppressive effect on dissociation of lymph factor, production of IL-2 and inflammation.