血管内皮生长因子在肝癌患者血清中的表达水平与肿瘤侵袭能力的相关性研究

Correlation between serum vascular endothelial growth factor levels and tumor invasion in primary hepatacellular carcinoma

目的探讨原发性肝癌患者血清血管内皮生长因子(VEGF)表达水平与肿瘤侵袭转移的关系。方法应用ELISA方法对30例原发性肝癌(PHC)患者、20例肝脏良性疾病患者及20例正常人血清中VEGF水平进行检测。结果PHC组与良性肝脏疾病及正常对照组中血清VEGF的含量比较,3组间有显著性差异(P<0.01);合并门脉瘤栓组血清VEGF含量明显高于无门脉瘤栓组血清VEGF含量(P<0.05);发生肝内转移组患者血清VEGF含量亦明显高于无肝内转移组患者血清VEGF含量(P<0.05)。结论PHC患者血清中VEGF水平显著高于正常人和良性肝病患者;患者血清中VEGF的高表达预示着PHC的高侵袭转移能力,可以作为评估PHC转移潜能、预测患者预后的有效指标之一。

Objective To explore the relationship between the level of vascular endothelial growthfactor （VEGF） in serum and tumor invasion of primary hepatocellular carcinoma （PHC）. Methods Measure the level of VEGF by ELISA in serum of 30 PHC patients, 20 benign liver disease patients and 20 healthy men. Results The level of VEGF in serum of group of PHC patients was significantly different from those of benign liver disease patients and of healthy men. The level of VEGF in serum of patients with portal tumor embolus was significantly higher than those haven＇t （P 〈 0. 05 ）. The level of VEGF in serum of group that with tumor metastasis in liver was also significantly higher than group that without tumor metastasis （P 〈 0.05）. Conclusion The level of VEGF in serum of PHC patients was obviously higher than those in benign liver disease patients and healthy people. Higher level of VEGF in serum PHC is highly invasive. Therefore, it can be used as an effective indicator to evaluate the metastasis and predict the prognosis of patients.