TRH兴奋试验垂体激素测定结果分析

TX To Assess the Results of Measuring Hypophysis Hormone on TRH Stimulating Test

对６８例ＴＲＨ兴奋试验患者同时测定ＦＳＨ、ＬＨ、ＰＲＬ。６８例中，男１７例，女５１例；平均年龄３９６岁。甲亢２２例和甲减２５例分为两个亚组：Ⅰ组为甲功已恢复正常，Ⅱ组仍为病理状态；其他２１例。结果：ＴＲＨ兴奋试验甲亢Ⅱ组呈无反应，其余各组呈正常或活跃反应；ＰＲＬ变化与ＴＳＨ一致，各病例组相同时相的ＰＲＬ和ＴＳＨ值对照，相关系数均在０９以上（ｐ＜００５）；ＦＳＨ、ＬＨ测定值各病例组及同一组各时相之间方差分析无显著性差异。讨论：ＴＳＨ、ＰＲＬ除甲亢病例外均有不同程度增加，而ＦＳＨ、ＬＨ无明显变化，此结果与文献报道相同。ＰＲＬ与ＴＳＨ具有良好的一致性，可用ＰＲＬ来取代ＴＳＨ作为ＴＲＨ兴奋试验的观测指标。甲亢ＰＲＬ对ＴＲＨ的反应低于其他病例组，提示甲状腺激素可能对ＰＲＬ的分泌有负反馈调节作用，类似于靶腺激素。

 group 68 patients(17 male,51 female),an average age of 316 years(range 11～65),were given TRH stimulating test.Both TSH and other hypophysis hormones(FSH,LH,PRL)were measured.Among 68 cases,22 hyperthyroid cases were divided two subgroups,as were 25 hypothysis cases.The patients of subgroup one had recovered there health and subgroup two suffered still from illness.There were 21 cases with various disease besides these patient.Results:hyperthyroid subgroup two failed to respond to TRH and all other subgroups had a normal or overnormal reaction.PRL was on an equally with TSH.Between PRL and TSH of all subgroups in same phase,relation coefficient was above 09(p<005).Neither value of FSH nor LH had differnce in all subgroups and all phases of same subgroup.Discuss:our results had proved by some eaasies.PRL could replace TSH as observation index of TRH stimulating because it was on an equally with TSH.In our paper,a response of PRL to TRH in hyperthyroid subgroup two was lower than all other.This result suggested thyroid hormone was one of the regulated factors for PRL secreting.Thyroid hormone reflectively inhibited hypophysis from secreting PRL and it was similar to hormone of target gland.