柯萨奇B组病毒在心血管疾病发生中的作用

Effect of Coxsackie virus B in genesis of cardiovascular disease

目的:了解柯萨奇B组病毒(CVB)在心脏疾病患者中的感染状况,探讨CVB感染与心血管疾病的内在关系。方法:采用间接酶联免疫吸附测定(ELISA)和反转录-聚合酶链反应(RT-PCR),进行CVBIgG抗体和核酸检测。结果:心脏病组CVB IgG阳性率为44.8%(112/250),对照组抗体阳性率为16.7%(18/108),两者有显著性差异(P<0.05)。CVB RNA检测结果显示,心脏病组阳性率为20.4%(51/250),对照组为3.7%(4/108),两者比较有显著性差异(P<0.05)。结论:在心脏病患者中CVB感染较普遍,应引起重视。

Objective： To study the infection of Coxsackie virus B （CVB） in cardiovascular disease and correlation between infection of CVB and cardiovascular disease. Methods： The enzyme-linked immunosorbant assay and reverse transcription polymerase chain reaction were performed to examined the CVB IgG antibody and nucleic acid. Results： The positive rate of CVB IgG antibody in cardiac disease group was 44. 8% （112/250）, and significant higher than that of control group （16.7%, 18/108）, P〈0.05. The positive rate of CVB RNA in cardiac disease group was 20.4% （51/250）, and significant higher than that of control group （3.7%, 4/108）, P〈0. 05. Conclusion： The infection of CVB is widespread in cardiovascular disease patients, must pay more attention to that.