五水头孢唑啉钠防治整形外科手术感染的临床研究

Clinical trial of cefazolin sodium pentahydrate in controlling postoperative infection of plastic operations

目的观察五水头孢唑啉钠（第1代头孢菌素）预防及治疗成年人各类切口的大、中型整形修复手术术后感染的疗效与安全性。方法成年人Ⅰ、Ⅱ类各种整形手术切口共246例,手术前预防性使用五水头孢唑啉钠1次,术后每日2次,每次静脉滴注2.0 g,疗程3-5天;Ⅲ类切口31例,术前2-3天,开始使用五水头孢唑啉钠,术后继续使用5-7天,每日2次,每次静脉滴注2.0 g。结果Ⅰ、Ⅱ类切口均一期愈合,无感染发生;Ⅲ类切口有效率80.6%,与感染菌种相关,总有效率为97.8%。3类切口总共发生轻度恶心等药物不良反应8例,发生率2.97%,未发现过敏反应及药物配伍禁忌。结论五水头孢唑啉钠控制整形外科手术后感染疗效显著,安全性较好。

Objective To observe the clinical efficacy and safety of cefazolin sodium pentahydrate for prevention and cure the postoperative infection of larger and middle operation of plastic operations. Methods A total of 246 of Ⅰ and Ⅱ incisal opening patients were administered at a dose of 2 g preoperatively, and the same dose after the operation, bid, for 3 to 5 days. A total of 31 Ⅲ incisal opening patients were administered at a dose of 2 g, bid, 2 or 3 days preoperatively, and the same dose after the operation, bid, for 5 to 7 days. Results All the patients of Ⅰ or Ⅱ incisal opening were primary healing and no infection. The effective power of m incisal opening was 80. 6%, effected by the kinds of bacteria. The total effective power was 97.8%. Total 8 cases had adverse drug reaction, the rate of which was 2.97 %. No allergic response and chemical incompatibility had been observed. Conclusion The cefazolin sodium pentahydrate had an excellent clinical efficacy and good safety profile in controlling postoperative infection of plastic operations.