摘要
目的观察五水头孢唑啉钠(第1代头孢菌素)预防及治疗成年人各类切口的大、中型整形修复手术术后感染的疗效与安全性。方法成年人Ⅰ、Ⅱ类各种整形手术切口共246例,手术前预防性使用五水头孢唑啉钠1次,术后每日2次,每次静脉滴注2.0 g,疗程3-5天;Ⅲ类切口31例,术前2-3天,开始使用五水头孢唑啉钠,术后继续使用5-7天,每日2次,每次静脉滴注2.0 g。结果Ⅰ、Ⅱ类切口均一期愈合,无感染发生;Ⅲ类切口有效率80.6%,与感染菌种相关,总有效率为97.8%。3类切口总共发生轻度恶心等药物不良反应8例,发生率2.97%,未发现过敏反应及药物配伍禁忌。结论五水头孢唑啉钠控制整形外科手术后感染疗效显著,安全性较好。
Objective To observe the clinical efficacy and safety of cefazolin sodium pentahydrate for prevention and cure the postoperative infection of larger and middle operation of plastic operations. Methods A total of 246 of Ⅰ and Ⅱ incisal opening patients were administered at a dose of 2 g preoperatively, and the same dose after the operation, bid, for 3 to 5 days. A total of 31 Ⅲ incisal opening patients were administered at a dose of 2 g, bid, 2 or 3 days preoperatively, and the same dose after the operation, bid, for 5 to 7 days. Results All the patients of Ⅰ or Ⅱ incisal opening were primary healing and no infection. The effective power of m incisal opening was 80. 6%, effected by the kinds of bacteria. The total effective power was 97.8%. Total 8 cases had adverse drug reaction, the rate of which was 2.97 %. No allergic response and chemical incompatibility had been observed. Conclusion The cefazolin sodium pentahydrate had an excellent clinical efficacy and good safety profile in controlling postoperative infection of plastic operations.
出处
《中国临床药理学杂志》
CAS
CSCD
北大核心
2009年第2期109-111,共3页
The Chinese Journal of Clinical Pharmacology
关键词
五水头孢唑啉钠
整形手术
术后感染
cefazolin sodium pentahydrate
plastic operations
postoperative infection