血清—腹水白蛋白梯度与食管静脉曲张破裂出血的关系

Relationship between Serum Ascites Albumin Gradient and Esophageal Variceal Bleeding

目的探讨血清—腹水白蛋白梯度(SAAG)在门脉高压性食管静脉曲张(esophageal varices,EV)破裂出血预测中的价值。方法测定57例肝硬化腹水患者SAAG值并行胃镜检查,以了解有无食管静脉曲张,以11g/L为界将57例患者分为高SAAG组及低SAAG组,采用χ2检验和Pearson相关分析法分析SAAG与食管静脉曲张之间的关系,并对食管静脉曲张伴出血和不伴出血者2组的SAAG值进行比较。结果57例患者中,并发食管静脉曲张破裂出血16例,非出血者41例,肝硬化并发食管静脉曲张破裂出血组的SAAG为(24.20±7.19)g/L,高于非出血组的(18.25±6.03)g/L,2组比较,差异有统计学意义(P<0.05)。结论SAAG与门脉压力密切相关,对预测门脉高压性食管静脉破裂出血有重要的临床价值。

[ Objective ] To explore the value of serum ascites albumin gradient （ SAAG ] in prediction of esophageal varices （ EV ] hemorrhage. [ Methods ] 57 patients with cirrhotic ascites were measured SAAG and examined with endoscopy to identify whether EV happened. The patients were divided into high SAAG group and low SAAG group by the value of 11 g/L. The relationship between SAAG and EV was analyzed by χ^2 test and Pearson correlation analysis. And the comparison was conducted between the SAAG value of EV with hemorrhage and that of non-hemorrhage. [ Results ] Of 57 patients, 16 had esophageal variceal bleeding, and 41 had no esophageal varieeal bleeding. SAAG of group with esophageal varieeal bleeding（ 24.20 ± 7.19） g/h was higher than that of group with no esophageal variceal bleeding（ 18.25 ± 6.03 ） g/L. The difference was significant between two groups（ P 〈 0.05）. [ Conclusion ] The level of SAAG is closely related with the portal venous pressure and has significant clinical value in prediction of esophageal vaiceal bleeding.