摘要
目的探讨阿托伐他汀治疗阿尔茨海默病(AD)的机制。方法将50只大鼠随机分为5组,除对照组外均建立AD模型,阿托伐他汀低、中、高剂量组分别予阿托伐他汀5、10、20 mg/kg药物水溶液灌胃,对照组、模型组给予等体积生理盐水灌胃,1次/d。10 d后行5 d水迷宫试验测试大鼠潜伏期,同时采用Western Blot法检测各组脑组织Caspase-12蛋白表达情况。结果与对照组比较,模型组潜伏期明显延长,脑组织中Caspase-12蛋白表达升高(P均<0.05);与模型组比较,阿托伐他汀低、中、高剂量组潜伏期明显缩短,脑组织中Caspase-12蛋白表达降低,中高剂量组更明显(P均<0.05)。结论阿托伐他汀可改善AD大鼠学习记忆能力,机制为降低Caspase-12表达。
Objective To investigate the mechanism of atorvastatin in treating Alzheimer＇s disease （AD）. Methods 50 rats were divided into 5 groups randomly and AD model were established except the control group. The low, middle , .high dose of atorvastatin group were lavaged with atorvastatin of 5,10,20 mg/kg respectively , while the same volume saline was given to the control group and model group,once a day for 10 days. Water maze assay was applied to test rats＇ ineubation.on period for 5 days. Western-Blot were adopt to test Caspase-12 expression in brain tissue. Results Compared with the control group,the incubation period of model group postponed and the expression of Caspase-12 protein in brain tissue increased significantly （ P 〈 0.05 ）. Compared with the model group, the incubation period of low, middle and high dose of atorvastatin group shortened and the expression of Caspase-12 protein in brain tissue decreased, in particular the middlee and high dose group （ P 〈 0.05 ）. Conclusion Atorvastatin can improve the remember capability and the mechanism of it maybe down-regulate the expression of Caspase-12.
出处
《山东医药》
CAS
北大核心
2009年第15期24-25,共2页
Shandong Medical Journal
