摘要
为探讨计算O/E法检验效能的方法和原理,提出O/E法样本含量的估计方法,利用Poisson分布及假设检验的原理,求出不同基线率π0、增长因子γ及样本含量下的检验效能。结果显示,检验效能1-β随基线率、样本含量、增长因子的增加而增加,且随着样本含量的增加,O/E法的检验效能的增加是不连续的,跳跃的,有时会有回复。计算O/E法检验效能的方法和原理,同样适用于Poison分布资料的假设检验。O/E法样本含量的估计方法,亦可用于疾病干预性研究中的样本大小的估计。
This paper addresses the methodology of calculating the power of O/E method and introduces the relevant algorithm for estimating the sample size.Based on the principles of hyporthesis testing and Poisson distribution,the power can be worked out for given sample size,baseline rate(π0) and the factor of increasing (γ).The power increases with the increase in sample size,π0 and γ.In shape the power is not a continuous smooth line but a zigzag line.The method illustrated in this paper can be also used for estimaging the sample size of studies on the intervention of diseases.
出处
《华西医科大学学报》
CAS
CSCD
1998年第1期66-69,共4页
Journal of West China University of Medical Sciences