染色质修饰酶在记忆中的作用

Role of Chromatin Modifying Enzymes in Memory

学习记忆的形成依赖于转录机制.近年研究发现,染色质修饰在基因表达调节中起重要作用.组蛋白乙酰化和去乙酰化是染色质修饰中最为常见调节方式,参与基因的转录调控.乙酰化可以激活转录,促进记忆的形成.组蛋白去乙酰化酶抑制剂可以增强突触可塑性,改善记忆损伤.因此,对于染色质修饰的深入研究,不仅有助于阐明记忆形成的分子机制,而且对记忆相关疾病的治疗以及新药物研发也具有重要指导意义.本文主要就组蛋白乙酰转移酶调节基因转录以及组蛋白去乙酰化酶抑制剂促进记忆形成的作用机理进行综述.

The formation of learning and memory depends on transcription mechanism. It has recently reported that chromatin modification plays an important role in regulation of gene expression. Histone acetylation and deacetylation are the most common forms involved in chromatin modification, which participate in gene transcription regulation. Acetylation can activate transcription and promote the memory formation. Histone deacetylase inhibitors can enhance synaptic plasticity and improve memory impairment. The further study of chromatin modification will not only help the understanding molecular mechanism of memory formation, but also provide a significant guidance for the treatment of memory-associated disease and research and development of new drugs. In this paper, we reviewed the mechanisms on histone acetyhransferases regulating gene transcription and histone deacetylase inhibitors promoting memory formation.