热量限制延长寿命的分子机制

Molecular Mechanisms of Extending Lifespan by Calorie Restriction

很多研究均发现,热量限制在很多物种中都有延长寿命的作用.这些报道认为,寿命的延长可能与氧化应激和炎症过程有关.值得注意的是,热量限制调节氧化应激与脂质代谢调控、抑制细胞凋亡、DNA保护等分子过程有密切关系.最近,有研究者表明,热量限制调控氧化应激和炎症过程是通过胰岛素/胰岛素样生长因子信号通路起作用的.热量限制在所有的动物模型实验中都显示延长寿命,然而,在人类中应用热量限制,可能还存在很多对人体健康问题值得关注.本文就热量限制如何调控寿命的机制的研究进展作一综述.

Many studies showed that calorie restriction could extend the lifespan in numerous species. Resuks in these reports suggested that the extension of lifespan was related to oxidative stress and inflammatory process. It was noticed that calorie restriction to regulate oxidative stress were closely related to many molecular processes, such as the regulation of lipid metabolism, the inhibition of cell apoptosis, and the protection from DNA damages. Recently, researchers have discovered that the insulin/1GF-1 signaling pathway might play an important role in calorie restriction under oxidative stress and the modulation of inflammatory responses. Since calorie restriction to extend the lifespan was shown in animal models, its relevance to human health became a concern of interest. In this review, recent proceedings on the mechanism of calorie restriction regulation will be presented.