妊娠期肝内胆汁淤积症甘胆酸水平与胎儿窘迫的关系

Relationship between the glycocholic and fetal distress in intrahepatic cholestasis of pregnancy

目的探讨妊娠期肝内胆汁淤积症(ICP)甘胆酸水平与胎儿窘迫的关系。方法108例ICP患者为研究组,50例正常孕妇为对照组,放射免疫法检测手术当天的甘胆酸水平,术中观察其羊水情况,对二者的关系进行分析。结果与对照组相比,甘胆酸超过20μg/mL时,其羊水粪染率显著增高,差异有统计学意义。并且随着甘胆酸水平的增高,其羊水粪染率逐渐增高。结论甘胆酸的水平超过20μg/mL时,应高度警惕胎儿宫内窘迫的发生。

Objective To explore the relationship between the glycocholic（LCA） profiles and fetal distress in intrahepatic cholestasis of pregnancy（ICP）. Methods Serum glycocholic profiles were studied in 108 ICP patients and 50 normal pregnant women using radioimmunity,the presence of meconium of amniotic fluid were inspected. Results A dramatic increasing of the presence of meconium rate of amniotic fluid when the LCA coneentrations〉20μg/rnL than those of normal pregnancy. Conclusion We propose LCA〉20gg/mL as one of biomarker of fetal distress in ICP patients.