去透明带地鼠卵穿透试验与人工授精受孕率关系的临床研究

Clinical significance of the zona-free hamster oocyte penetration in intrauterine insemination.

对１１８对不孕夫妇，拟采用ＩＵＩ前用ＨＯＰ系统检测男方精液，并以精子穿卵率为指标进行分组，统计ＩＵＩ的受孕率。结果：１１８例的４１２个治疗周期中，第一组：穿卵率≥１５％的患例，ＩＵＩ受孕率为４２％；第二组：１０％≤穿卵率＜１５％的患例，ＩＵＩ受孕率为１３％；第三组：穿卵率＜１０％者，ＩＵＩ受孕率为２％。第一组与第二、三组间其受孕率有明显差异，经统计学检验有显著意义（Ｐ＜０．００５）。结果表明，采用ＨＯＰ作为ＩＵＩ病例筛选指标，提高ＩＵＩ的成功率，对不孕症病因诊断与治疗具有重要的临床实用价值。

 Objective:To value the significance of the zona-free hamster oocyte penetration test(HOP)in intrauterine insemination(IUI).Design:One hundred and eighteen women with infertility were included in this study.Semen of their husbands were acquired by masturbation.The semen were transfered to a specific sterile medium.High active sperm used for IUI was gathered by means of sperm swimming up and washed.Before these women received IUI treatment,HOP precentage of their husbands sperm were acquired.The women were divided into three groups according to the HOP percentage.The first group:HOP percentage≥15%,the second group:10%≤HOP percentage<15%,the third group:HOP percentage<10%.Result:Pregnancy rate of the first group was 42%,the second group was 13%,the third group was only 2%.Pregnancy rete of the first group was significantly higher than that of the second and the third group respectively(P<0.005).Conclusion:We suggested that HOP might serve as an indicator of IUI cases collection. \ \