血管性痴呆及阿尔茨海默病患者血清甘油三酯和总胆固醇的变化

A Clinical Study on the Serum Triglyceride and Total Cholesterol of Patients with Vascular Dementia and Alzheimer's Disease

目的探讨血管性痴呆(VD)和阿尔茨海默病(AD)患者血清甘油三酯(TG)及总胆固醇(TC)含量的变化和临床意义。方法检测54例血管性痴呆和78例阿尔茨海默病患者血清中TG及TC的含量并与50名正常人对照。结果AD组与VD组血清TG[(1.98±0.98)mmol/L,(2.13±1.01)mmol/L]及TC[(6.52±1.42)mmol/L,(6.36±1.15)mmol/L]均高于对照组[(1.32±0.88)mmol/L,(5.45±0.93)mmol/L],差别有统计学意义(P<0.05),且VD组TG水平与对照组相比,差别有统计学意义(P<0.01),而AD组与VD组之间无统计学意义(P>0.05)。结论AD和VD患者血清TG及TC含量明显增高,降低TG及TC可能对AD和VD的预防和治疗有益。

Objective To explore the change and clinical significance of serum triglycerides and total cholesterol of patients with Vascular dementia （VD） and Atzbeimer＇s disease （AD）. Methods 54 cases of VD and 78 cases of AD were examined. 50 cases of healthy adult were enrolled as the control group. Results The serum triglyceride [（1.98±0.98） mmol/L, （12.13±1.0） mmol/L] in VD patients and total cholesterol [（6.52±1.42 mmol/L, （6.36±1.15） mmol/L] in AD patients were significantly higher than those of the control group [（1.32±0.88） mmoL/L（5.45±0.93） mmoL/L]（P〈0.05）. There was significant difference in TG between the VD group and the control group （P〈0.01）, but there was no difference between the AD and the VD group （P〉0.05）. Conclusion The serum triglyceride and total cholesterol of patients with VD and AD were much higher than those of normal healthy persons. It is conducive to lower the triglyceride and total cholesterol for the prevention and treatment of these two diseases.