利培酮替换氯氮平治疗慢性精神分裂症

The Clinical Study on Risperidone Replacing Clozapine in the Treatment of Chronic Schizophrenia

目的探讨利培酮替换氯氮平治疗慢性精神分裂症的疗效及不良反应。方法对60例用氯氮平治疗的慢性稳定期精神分裂症患者换用利培酮治疗,观察12周,在换药前和换药后第4、8、12周末用阳性和阴性症状量表(PANSS)和不良反应症状量表(TESS)评定疗效及药物的不良反应。结果利培酮和氯氮平治疗慢性精神分裂症疗效相当,12周后PANSS阳性症状分、总分与换药前比较,差别无统计学意义(P>0.05),PANSS阴性症状分与换药前比较,差别有统计学意义(P<0.01)。换用利培酮后可以进一步改善阴性症状,且不良反应少。结论利培酮替换氯氮平治疗慢性精神分裂症疗效好,不良反应轻,患者服药依从性好。

Objective To compare the efficacy and safety of rispredone and Clozapine in the treatment of chronic schizophrenia. Methods 60 inpatients with chronic schizophrenia who took clozapine were treated by risperidone for 12 weeks. Effects and side effects were assessed with PANSS and TESS respectively before and after 4, 8, 12 weeks treatment. Results Risperdone was as effective as clozapine in the treatment of schizophrenia, after 12 weeks treatment there were no significant differences in the positive score of PANSS and total score （t= 1.52, t= 1.59, P〉0.05）, and there was significant differences in the negative score of PANSS （t=6.13, P〈0.01）, Risperidone replacement could further improve negative symptoms and less side effects than clozapine. Conclusion Rispredone replacing clozapine is effective in the treatment of chronic schizophrenia with less side effects and good compliance.