摘要
目的研究抗坏血酸有机锗倍半氧化物对鸡胚尿囊膜(CAM)血管生成的抑制作用。方法在七日龄CAM上植入含不同剂量试药的甲基纤维素膜片,并孵化48 h。解剖显微镜下计数加药组和对照组局部血管数,以此来反映试药对CAM新生血管形成的影响。结果抗坏血酸有机锗倍半氧化物2.5,1.5,0.5 mg/egg剂量相关性减少CAM局部的血管数。结论抗坏血酸有机锗倍半氧化物对CAM新生血管有显著的抑制作用。
Objective To investigate the antiangiogenesis effect of the ascorbic Acid SesquioxyGe（Ⅳ） on chicken embryo chorioallantoic membrane （CAM）. Methods The ascorbic acid SesquioxyGe （Ⅳ ） loaded with methylcellulose membranes was applied on chicken CAM surface of 7 - day - old eggs and incubated for 48 hours . Local vessel density was measured under dissection microscope . The inhibitory effect on CAM angiogenesis was evaluated. Results The Ge（Ⅳ ） complex with ascorbic acid at 2.5,1. 5 rag/egg and 0.5 mg/egg dose - dependently decreased the density of local blood vessels. Conclusion Ascorbic acid Sesquioxy- Ge（ Ⅳ ） significantly inhibits chicken CAM angiogenesis .
出处
《时珍国医国药》
CAS
CSCD
北大核心
2009年第4期897-899,共3页
Lishizhen Medicine and Materia Medica Research
基金
黑龙江省自然科学基金(No.2004-04)
