阿立哌唑与氯氮平治疗精神分裂症对照研究的Meta分析

A meta-analysis on comparison between aripiprazol and clozapine in the treatment of schizophrenia

目的:探讨阿立哌唑与氯氮平治疗精神分裂症的疗效和不良反应的差异。方法:应用Meta分析对13项阿立哌唑与氯氮平治疗精神分裂症对照研究的文章进行再分析,评价其合并效应量大小和综合显著性检验。结果:阿立哌唑自身对照比较的治疗效应极大,合并效应量d=-3.81,95%CI(-7.43,-0.19),χ2=156.13,P<0.01;阿立哌唑与氯氮平在治疗2周末和治疗后组间的比较疗效差异无显著性,差异效应偏小,分别为Y合并=0.02,95%CI(-012,0.15),χ2=0.20,P>0.05;Y合并=-0.003,95%CI(-0.13,0.13),χ2=2.04,P>0.05;阿立哌唑的不良反应显著少于氯氮平。结论:阿立哌唑与氯氮平的疗效相仿,但阿立哌唑不良反应少。

Objective： To explore the differences of efficacy and side effects between aripiprazol and clozapine in the treatment of schizophrenia. Method： 13 comparative studies of aripiprazol and clozapine in the treatment of schizophrenia were analyzed by meta-analysis in efficacy and side effects. Results： Self-controlled studies showed therapeutic effect of aripiprazol was great, d = - 3.81,95 % CI（ - 7.43, - 0.19 ）, x2 = 156.13, P 〈 0.01. No significant difference was found between aripiprazol and clozapine after 2 weeks and throughout the treatment, the efficacy difference was not significant. Y = - 0.02,95% CI（ - 0.12,0. 15 ）, X2 = 0.20, P 〉 0.05 ; Yco = - 0.003,95% CI（ -0. 13,0.13 ）, x2 = 2.04, P 〉 0.05. Side effects were slighter in aripiprazol group than in clozapine group. Conclusion： Therapeutic effects of aripiprazol and clozapine for schizophrenia are similar, but aripiprazol shows fewer side effects.