阿立哌唑对利培酮所致高催乳素血症的疗效

Efficacy of aripiprazole treatment for risperidone-induced hyperprolactinemia

目的:探讨阿立哌唑治疗利培酮所致高催乳素血症的有效性和安全性。方法:对19例利培酮所致高催乳素血症的男性精神分裂症患者,合并阿立哌唑10 mg/d。分别于治疗前、治疗2、4、8周检测血清催乳素水平;在治疗前、治疗8周评定阳性与阴性症状量表(PANSS)、临床总体印象量表-疾病严重度(CGI-S)、Barnes锥体外系不良反应量表(SAS)、Barnes静坐不能量表(BAS)和UKU不良反应量表(UKU)。结果:治疗4周催乳素水平显著下降(P<0.001),而治疗4周与治疗8周催乳素水平差异无显著性(P>0.05);研究结束时,所有患者催乳素水平下降超过50%,其中6例降至正常,5例患者催乳素相关症状均有改善;治疗前后PANSS、CGI-S、BAS和SAS评分差异无显著性(P>0.05)。结论:阿立哌唑可有效治疗利培酮所致的高催乳素血症,不良反应少。

Objective：To explore the efficacy and safety of adjunctive treatment with aripiprazole on hyperprolactinemia induced by risperidone. Method： 19 male schizophrenic patients with hyperprolactinemia induced by risperidone received 10 mg/d aripiprazole for adjunctive treatment. Serum prolaetin levels were measured before treatment and 2,4 and 8 weeks after treatment. Positive and negative symptom scale（ PANSS）, clinical global impression scale-severity （ CGI-S）, Simpson-Angus scale （ SAS ）, Barnes-Akathisia scale and Ud- valg for kliniske undersogelser side effect rating scale （UKU） were assessed before treatment and after 8 weeks treatment. Results： Prolaetin levels reduced significantly over time during 4 weeks after treatment （ P 〈 0.001 ）, but there was no significant difference between 4 weeks and 8 weeks （ P 〉 0.05 ）. At end point, prolae- tin levels of all patients reduced by 50% and 6 out of 19 patients had prolaetin levels within normal range. 5 pa- tients experiencing prolactin-related symptoms reported improvement. There were no significant changes on the total score of PANSS, CGI-S, BAS and SAS （ P 〉 0.05 ）. Conclusion： Aripiprazole may be useful for resolving risperidone-induced hyperprolactinemia with little side effect.