RmhTNF治疗恶性腹水疗效观察

Oberserveation on the therapeutic effect of rmh-TNF in treating malignant ascites

【目的】探讨重组人改构肿瘤坏死因子(recombinant mutant human tumor necrosi factor,rmhTNF)治疗恶性腹水的疗效和毒副反应。【方法】60例恶性腹水患者随机分成2组,顺铂组(DDP组)和肿瘤坏死因子组(tu-mor necrosis factor,TNF组),每组30例,患者排尽腹腔积液后,注入顺铂20 mg或加热后的rmhTNF 1 500万单位,3次/周,观察临床效果、起效时间、生活质量及副反应。【结果】TNF组及DDP组总有效率分别为90%、68%;起效时间分别为7.2、10.5 d。TNF组不良反应轻,生活质量提高,与DDP组比较差异有统计学意义(P<0.05)。【结论】rmhTNF局部治疗恶性腹水疗效可靠,副作用小,起效时间短,生活质量提高,是治疗恶性腹水的有效药物,尤其是治疗因恶性腹水不能耐受全身静脉化疗的患者。

[Objective] To investigate the clinical efficacy and side effects of rmh-TNF in the treatment of malignant ascites. [Methods] Sixty patients with malignant ascites were divided randomly into Group rmh-TNF （TNF） and Group cisplatin （DDP） to observe the clinical efficacy, time to response, quality of life and side effects. DDP or heated rmh-TNF was injected into abdominal cavity three times per week after all ascites were arained. [Results] The total effective rate in Group TNF and Group DDP was 90% and 68% respectively; and the time to response was 13.5 days and 8.4 days respectively. The quality of life was strikingly better than that in Group DDP; The side effects were less in Group TNF than Group DDP, and there was statistical sig- nificanceao compared with Group DDP （ P 〈 0.05）. [ Conclusions] The rmh-TNF is effective with minor side effects in the treatment of malignant ascites, within short time, improve the quality of life. Therefore it is a favor＇able treatment of choice, especially to that who can＇t tolerant chemotherapy in vein with malignant ascites.