尿脱氧吡啶啉排泄率是糖尿病骨量减少的敏感指标

Urinary excretion of deoxypyridinoline: a sensitive marker in diabetic low bone mass

目的探讨尿脱氧吡啶啉（ＤＰＤ）排泄率对骨量减少的诊断意义。方法对４７例（男２７例，女２０例）糖尿病患者和４０例（男２０例，女２０例）正常健康人用ＥＬＩＳＡ双抗体夹心法测定尿脱氧吡啶啉排泄率。结果糖尿病患者ＤＰＤ排泄率（男５．８９±１．９３，女６．０１±２．２２ｎｍｏｌＬ－１ＤＰＤ／ｍｍｏｌＬ－１Ｃｒ）较正常对照组（男３．８７±１．５７，女３．６３±１．６８ｎｍｏｌＬ－１ＤＰＤ／ｍｍｏｌＬ－１Ｃｒ）明显增高（Ｐ＜０．０１）。而部分糖尿病患者骨密度降低尚达不到骨质疏松或骨量减少的诊断标准。结论ＤＰＤ排泄率是反映糖尿病骨量减少的敏感指标。

Objective To study diagnostic value of urinary excretion of deoxypyridinoline in low bone mass.Methods The urinary excretion of deoxypyridinoline with ELISA method and the bone mineral density of femur (neck, wards and troch) and lumbales 2～4 with DEXA were measured in 47 patients (27 men, 20 women) with NIDDM and 40 controls (20 men, 20 women).Results The excretion of DPD in patients with NIDDM (men 5.89±1.93, women 6.01±2.22 nmol·L -1 DPD/ mmol· L -1 Cr) was significantly increased as compared to the controls (men 3.87±1.57, women 3.63± 1.68 nmol·L -1 DPD/mmol·L -1 Cr) ( P <0.01). The bone mineral density however was less decreased, and was not up to the standard of oesteoporosis or low bone mass in some patients.Conclusion The excretion of DPD is a sentitive marker in diabetic low bone mass.