食管早期鳞癌中CD56、NSE、PCNA的表达及意义

EXPRESSION AND SIGNIFICANCE OF CD56,NSE AND PCNA IN EARLY ESOPHAGEAL SQUAMOUS CELL CARCINOMA

目的探讨神经内分泌分化对早期食管鳞状细胞癌的预后意义。方法采用免疫组织化学方法检测48例食管早期鳞状细胞癌上神经内分泌指标 CD56、神经元特异性烯醇化酶(neuron—specific enolase,NSE)的表达情况及其与增殖指标增殖细胞核抗原(proliferating cell nuclear antigen,PCNA)及预后的关系。结果 CD56、NSE在48例早期食管鳞状细胞癌中阳性表达率分别为33.3%、22.9%;CD56的阳性表达与食管鳞癌的浸润深度、分化无明显关系(P>0.05)。NSE 的阳性表达与食管鳞癌的浸润深度无关(P>0.05);NSE 与食管鳞癌的分化有关(P<0.05)。CD56、NSE 的阳性表达与 PCNA 相关(r=0.299,P<0.05;r=0.288,P<0.05)。COX 回归模型仅显示肿瘤的分化和分期为独立的预后指标。结论神经内分泌分化与早期食管鳞状细胞癌的预后无明显相关性,不能作为估计预后的指标。

Objective To evaluate the prognostic significance of neuroendocrine differentiation in early esophageal squamous cell carcinoma （ESCC）. Methods Expressions of CD56,neuron-specific enolase（NSE） and proliferating cell nuclear antigen（PCNA） in 48 cases of ESCC were detected by immunohistochemical method and their prognostic significances in early ESCC were studied. Results Positive rate of CD56 and NSE was 33.3~ and 22.9~ respectively. Expression of CD56 was not correlated with the depth of invasion and differentiation（ P 〉0.05）. Expression of NSE was not correlated with the depth of invasion （ P 〉0.05） ,correlated with the differentiation（ P 〈0.05）. CD56 and the expression of NSE were correlated with that of PCNA（ r = 0. 299, P 〈 0.05; r = 0. 288, P 〈 0.05）. COX regression only revealed that tumor differentiation and stage were independent prognostic factors. Conclusion There is no correlation between neuroendocrine differentiation and prognosis of ESCC.