丙氨酰-谷氨酰胺治疗老年慢性阻塞性肺疾病急性加重期的临床观察

Effects of alanyl glutamine on acute exacerbation of chronic obstructive pulmonary disease in aged patients

目的探讨丙氨酰谷氨酰胺对慢性阻塞性肺疾病急性加重期患者(AECOPD)的治疗作用。方法选择60例AE-COPD患者,随机分为治疗组和对照组,各30例。对照组给予常规临床治疗,抗生素使用14d。治疗组在对照组的基础上加用丙氨酰谷氨酰胺治疗,观察两组治疗前、治疗第10天及第14天的动脉血气,治疗前及治疗第14天的肝肾功能、血清白蛋白、总蛋白的变化,并评价治疗效果。结果治疗组动脉血气分析在第10天与对照组比较有统计学差异(P<0.05),治疗期间各营养指标明显高于对照组(P<0.05),肝肾功能无统计学差异(P>0.05),疗效评价治疗组与对照组相比有统计学差异(P<0.05)。结论联合应用丙氨酰谷氨酰胺对AECOPD患者有明显的治疗作用。

Objective To evaluate the value of alanyl glutamine in the treatment of aged patients with acute exacerbation of chronic ob- structive pulmonary disease（AECOPD）. Methods Sixty aged patients with AECOPD were randomly divided into two groups：control group（ n = 30）and treatment group（ n = 30）. The patients in control group were given the conventional treatment for 14 d, and patients in treatment group were given alanyl glutamine for 14 d based on conventional treatment. Before and after treatment, the arterial blood gas analysis was observed,liver and kidney functions, seralbumin and total serum protein were detected, and the clinical effects were e- valuated. Results At day 10, the arterial blood gas analysis in treatment group was better than that in control group （P 〈 O. 05）. Dur- ing the whole treatment, all nutrition indices were higher than that in control group （P 〈 O. 05）. The clinical effects in treatment gr^p were better than that in control group（ P 〈 0.05 ）, but the liver and kidney functions showed no significant difference between two groups （ P 〉 O. 05）. Conclusion Conventional treatment combined with alanyl glutamine could effectively treat AECPD in the aged patients.