盐酸雷莫司琼在预防术后恶心呕吐的临床研究

Clinical study on intravenous injection of ramosetron for preventing postoperative nausea and vomiting

目的探讨雷莫司琼预防手术后恶心呕吐的效果。方法75例择期在全身麻醉下行普外科手术的病人,按随机数字表随机分为3组:A组(雷莫司琼组,n=25),在麻醉诱导前静脉给予雷莫司琼0.3mg;B组(昂丹司琼组,n=25),麻醉诱导前静脉给予昂丹司琼4mg;C组(对照组,n=25),麻醉诱导前静脉注射0.9%生理盐水10ml。观察每位病人手术后24h的恶心、呕吐发生率。结果术后24h雷莫司琼组和昂丹司琼组恶心呕吐发生率分别为8%和12%,显著低于对照组48%(P<0.05)。结论雷莫司琼能安全、有效的预防术后恶心呕吐的发生。

Objective To study the efficacy of ramosetron for preventing postoperative nausea and vomiting. Methods A total of 75 patients performing selective surgery were divided into three groups ： ramosetron group, ondensetron group and placebo group. Before anesthesia induction,the patients were given 0.3 mg ramosetron in ramosetron group,4 mg ondensetron in ondensetron group,while 10 ml normal saline in placebo group. The nausea and vomiting were observed and recorded after surgery for 24 h. Results The postop- erative nausea and vomiting was significantly lower in ramosetron group（8%） and ondensetron group（12%） than that in placebo group （48%,P 〈 0.05 ）. Conclusion Ramosetron could effectively prevent postoperative nausea and vomiting.