婴儿肝炎综合征患儿血清转氨酶、胆红素、血脂及维生素E浓度的相关性研究

Study on correlations of serum transaminase,bilirubin,serum lipids and Vitamin E in IHS

目的探讨婴儿肝炎综合征患儿血清转氨酶、胆红素、血脂及维生素E浓度的相关性。方法回顾性比较、分析60例确诊为非胆道闭锁婴儿肝炎患儿的血清转氨酶、血脂及维生素E浓度的相关性。结果直接胆红素与总胆固醇之间有明确的正相关(r=0.314,P=0.015),DB与维生素E之间有明确的负相关(r=-0.435,P=0.001),丙氨酸转氨酶(r=-0.361,P=0.006)和门冬氨酸转氨酶(r=-0.421,P=0.001)与维生素E之间有明确的负相关,补充维生素E可显著降低总胆红素(P<0.01)和直接胆红素(P<0.05)水平,同时还显著改善总胆固醇(P<0.05)和甘油三酯(P<0.01)浓度。结论补充维生素E具有保护肝细胞膜,辅助改善婴儿肝炎综合征患儿的肝功能,进而促进胆汁排泄、降低胆红素和血脂水平。

Objective To investigate the correlation of serum transaminase, bilirubin, serum lipids and Vitamin E in infantile hepatitis syndrome（IHS）. Methods To analyze and compare the relevance of serum transaminase, serum lipids and Vitamin E retrospectively, in 60 IHS cases with non-biliary atresia. Results It was significant of the positive correlation between direct bihrubin（DB） and total cholesterol （r = 0.314, P = 0.015 ）, and obvious negative correlation was found between DB and Vitamin E（r= -0. 435, P = 0.001 ）. With the level of Vitamin E, alanine aminotransferase（r = -0.361, P =0.006） and aspartate aminotransferase（ r = - 0.421, P = 0.001 ） have specific negative correlation. Vitamin E can significantly reduce the level of total bilirubin（P 〈0.01 ） and DB（P 〈 0.05 ）, it was also helpful to ameliorate total cholesterol （P 〈 0.05 ） and triglycerides （P 〈 0.01 ）. Conclusion Supplying Vitamin E properly can be assisted to improve liver function, reduce bilirubin and serum lipid level of the IHS patients.