电磁脉冲对肿瘤细胞杀伤效应研究进展
摘要
随着电磁物理学与生物工程的发展，国际上兴起一种合理控制电磁脉冲，能使细胞出现可逆性电击穿及不可逆性电击穿，为肿瘤的治疗开辟了新路径。据实验表明，合理控制电磁脉冲可直接对肿瘤细胞造成不可逆性电击穿致不可逆性杀伤；也可对肿瘤细胞形成可逆性电击穿，联合化疗药物治疗可大大增加药物对细胞膜渗透作用，强化药物效应。目前，上述研究尚处于起步阶段，很多机制尚未阐明，现笔者结合中外文献，对目前实验成果综述如下。
出处
《实用肿瘤学杂志》
CAS
2009年第2期170-174,共5页
Practical Oncology Journal
参考文献30
-
1Eva Nilsson, Jaak Berendson, Eduardo Fontes. Development of a dosage method for electrochemical treatment of tumours : a simplified mathematical model [ J ]. Bioelectrochemistry and Bioenergetics,2003, (47) :11- 18.
-
2Eva Nilsson, Jaak Berendson, Eduardo Fontes. Electrochemical treatment of tumours: a simplified mathematical model [ J ]. Journal of Electroanalytical Chemistry, 1999, ( 460 ) :88 -99.
-
3Eva Nilsson, Eduardo Fontes. Mathematical modeling of physicochemical reactions and transport processing occurring around a platinum cathode during the electrochemical treatment of tumours [ J ]. Bioelectrochemistry ,2001, ( 53 ) : 213 - 224.
-
4Kostadin Brandiaky, Ivan Daskalov. Electrical field and current distributions in electrocheotherapy[J]. Bioelectrochemistry and bioenergetics,2004, (48) :201 - 208.
-
5Lluis M. Mir, Stephane Orlowski. Mechanisms of electrochemotherapy [ J ]. Advanced drug delivery reviews, 1999, (35) :107 - 118.
-
6Richard Heller, Richard Gilbert, Mark J, et al. Clinical apphcations of electrochemotherapy [ J ]. Advanced Drug Delivery Reviews,1999, (35) :119 - 129.
-
7Hofmann GA, Dev SB, Dimmer S, et al. Electroperation therapy: a new approach for the treatment of head and neck cancer [ J ]. IEEE Transaction on Biomedical Engineering,1999,46 (6) :752 - 759.
-
8米彦,姚陈果,熊兰,孙才新,胡丽娜.电穿孔疗法在头颈癌治疗中的应用[J].国外医学（生物医学工程分册）,2001,24(5):234-237. 被引量：2
-
9Semrov D, Miklav~i~ D. Calculation of the electrical parameters in eleetroehemotherapy of solid turnouts in mice [ J ].Computers in Biology and Medicine, 2006, (28):439 - 448.
-
10Damijan Miklavcic, Dejan Semrov, Hatima Mekid, et al. A validated model of in vivo electric field distribution in tissues for eleetrochemotherapy and for DNA eleetrotranfer for gene therapy [ J ]. Biochimica et Biophysica Acta, 2000, (1523) :73 - 83.
二级参考文献10
-
1Hofmann GA,Dev SB,Nanda GS.Electrochemother apy: Transition from laboratory to the clinic[].IEEE Engineering in Medicine and Biology Magazine.1996
-
2Panje WR,Hier MP,Garman GR,et al.Electroporation therapy of head and neck cancer Ann Otol Rhinol[].Laryngologie Rhinologie Otologie.1998
-
3Rudolf Z,Staduc B,Cemazar M,et al.Electrochemotherapy with bleomycin: The first clinical experience in malignant melanoma patients[].Radiation Oncology.1995
-
4Nanda GS,Mishra KP.Studies on electroporation of thermally and chemically treated human erythrocytes[].Bioelectrochemistry and Bioenergetics.1994
-
5Miklavcic D,Beravs K,Semrov D,et al.The Importance of electric field distribution for effective in vivo electroporation of tissues[].Biophysical Journal.1998
-
6Nishi T,Yoshizato K,Yamashiro S,et al.High efficiency in vivo gene transfer using intra arterial plasmid DNA injection following in vivo electroporation[].Cancer Research.1996
-
7Parker SL,Tong T,Bolden S,et al.Cancer statistics[].CA A Cancer Journal for Clinicians.1996
-
8Sauer H,Putz V,Fischer K,et al.Increased doxorubicin uptake and toxicity in multicellular tumour spheroids treated with DC electrical fields[].British Journal of Cancer.1999
-
9Jaroszeski MJ,Gilbert RA,Heller R.In vivo antitumor effects of electrochemotherapy in a hepatoma model[].Biochemistry and Biophysics.1997
-
10Tyuin M,Padda R,Huang KX,et al.Electrotransfor mation of clostridium acetobutylicum ATCC 824 using hiht -votage radio frequency modulated square pulses[].Jounal of Applied Microbiology.2000
-
1杨果,王保义,张弘,陈海川,王子淑,杨孔,孙敬儒.电磁脉冲提高抗肿瘤药物的细胞毒性的研究[J].生物医学工程学杂志,2003,20(3):497-499. 被引量：4
-
2吴彦卓,贾宇峰,郭鹞,郑振兴,周晏.电磁脉冲对小鼠脑内儿茶酚胺类物质含量的影响[J].第四军医大学学报,1997,18(5):423-423. 被引量：10
-
3高立伟,贾倞,朱京丽.直肠癌术前放疗的研究进展[J].中日友好医院学报,2009,23(1):53-55.
-
4曾浩,张弘,王保义,王新民,王子淑,岳碧松,邹方东,耿芹.利用电磁脉冲提高抗癌药物治疗肿瘤细胞疗效的实验研究[J].山东生物医学工程,2003,22(1):5-7.
-
5曾浩,张弘,王保义,王新民,王子淑,岳碧松,邹方东,耿芹.利用电磁脉冲提高抗癌药物治疗肿瘤细胞疗效的实验研究[J].上海生物医学工程,2003,24(3):23-26.
-
6孔伟.紫杉类联合蒽环类方案新辅助化疗在乳腺癌治疗中的近期疗效观察[J].临床医药文献电子杂志,2016,3(58):11641-11641.
-
7齐亚军,刘健,曹云祥,孙玥,王芳,王亚黎.风湿病的氧化应激及干预研究进展[J].中华中医药学刊,2013,31(12):2606-2609. 被引量：12
-
8高惠丽,姚婉贞.慢性阻塞性肺疾病和血糖[J].国际呼吸杂志,2008,28(17):1070-1072. 被引量：3
-
9杨孔,王子淑,邹方东,陈文元,王喜忠,郭聪,岳碧松,王保义,张弘,杨果,陈海川.利用电穿孔提高抗肿瘤药物细胞毒性的初步研究[J].四川大学学报（自然科学版）,2002,39(S1):166-169. 被引量：3
-
10杨孔,王子淑,郭聪,邹方东,王喜忠,王保义,张弘,刘长军.电磁脉冲各参数对HeLa细胞可逆穿孔影响的研究[J].四川大学学报（自然科学版）,2001,38(4):575-579. 被引量：6
