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脆性组氨酸三联体基因与宫颈癌的研究进展 被引量：1

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摘要 宫颈癌是造成妇科肿瘤患者死亡的第二大原因。多年来人们一直在寻找肿瘤初期即发生结构和功能异常的基因。1996年，Ohta等利用外显子捕获法在染色体3p14．2处发现一个新基因，其编码的蛋白质与组氨酸三体蛋白高度同源，而且该基因跨越了人类染色体最常见的脆性部位FRA3B，因此命名为脆性组氨酸三联体（fragile histidine triad，FHIT）基因，
作者 张长青(综述) 王晶(审校)
机构地区 哈尔滨市第五医院 哈尔滨医科大学附属肿瘤医院
出处 《实用肿瘤学杂志》 CAS 2009年第2期197-200,共4页 Practical Oncology Journal
基金 黑龙江省卫生厅资助项目（编号：2005-69）
关键词 脆性组氨酸三联体基因 宫颈癌 染色体3p14.2 妇科肿瘤患者 FRA3B 人类染色体 功能异常 脆性部位
分类号 R734.202 [医药卫生—肿瘤] R737.33 [医药卫生—肿瘤]
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参考文献23

  • 1Campiglio M, Blanchi F, Andriani F, et al. Dadenosines as FHIT - Ness instructors [ J ]. J Cell Physiol, 2006,208 (2) : 274 - 281.
  • 2Zanesi N, Pekarsky Y, Croce CM. A mouse model of the fragile gene FHIT: From carcinogenesis to gene therapy and cancer prevention [ J ]. Mutat Res,2005,591 ( 1 - 2) : 103 - 109.
  • 3Fujishita T, Doi Y, Sonoshita M, et al. Development of spontaneous tumours and intestinal lesions in Fhit gene knockout mice [ J ]. Br J Cancer,2004,91 (8) : 1571 - 1574.
  • 4Pekarsky Y, Zanesi N, Palamarchuk A, et al. FHIT: from gene discovery to cancer treatment and prevention[ J]. Lancet Oncol,2002,3(12) :748 -754.
  • 5Shi Y, Zou M, Farid NR, et al. Association of FHIT ( fragile histidine triad), a candidate tumor suppressor gene, with the ubiquitin - conjugating enzyme nUBC9 [ J ]. Biochem J, 2000,352(2) :443 -448.
  • 6Ishii H, Zanesi N, Vecchione A, et al. Regression of upper gastric cancer in mice by FHIT gene delivery [ J ]. FASEB J, 2003,17(12) : 1768 - 1770.
  • 7Garinis GA, Gorgoulis VG, Mariatos G, et al. Association of allelic loss at the FHIT locus and p53 alterations with tumour kinetics and chromosomal instability in non small ten lung carcinomas ( NSCLCs ) [ J ]. J Pathol, 2001,193 (1) :55 -65.
  • 8石海燕,陈晓端.子宫颈癌FHIT基因表达与杂合性丢失[J].临床与实验病理学杂志,2004,20(1):56-59. 被引量：4
  • 9Wu Y, Meng L, Wang H, et al. Regulation of DNA methylation on the expression of the FI-IIT gene contributes to cervical carcinoma cell tumorigenesis [ J ]. Oncol Rep, 2006,16 (3) :625 -629.
  • 10Ren CC, Miao XH, Yang B, et al. Methylation status of the fragile histidine triad and E - eadherin genes in plasma of cervical cancer patients [ J ]. Im J Gynecol Cancer, 2006, 16(5) :1862 - 1867.

二级参考文献24

  • 1[1]Wistuba II, Montellano FD, Milchgrub S, et al. Deletions of chromosome 3p are frequent and early events in the pathogenesis of uterine cervical carcinoma. Cancer Res, 1997,57(15):3154～8.
  • 2[2]Ohta M, Inoue H, Cotticelli MG, et al. The FHIT gene, spanning the chromosome 3p14.2 fragile site and renal carcinoma-associated t(3;8) breakpoint, is abnormal in digestive tract cancers. Cell, 1996,84(4):587～97.
  • 3[3]Nishimura M, Furumoto H, Kato T, et al. Microsatellite instability is a late event in the carcinogenesis of uterine cervical cancer. Gynecol Oncol, 2000,79(2):201～6.
  • 4[4]Greenspan DL, Connolly DC, Wu R, et al. Loss of FHIT expression in cervical carcinoma cell lines and primary tumors. Cancer Res, 1997,57(21): 4692～8.
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  • 6[6]Hao XP, Willis JE, Pretlow TG, et al. Loss of fragile histidine triad expression in colorectal carcinomas and premalignant lesions. Cancer Res, 2000,60(1):18～21.
  • 7[7]Gotte K, Hadaczek P, Coy JF, et al. FHIT expression is absent or reduced in a subset of primary head and neck cancer. Anticancer Res, 2000,20(2A):1057～60.
  • 8[8]Negrini M, Monaco C, Vorechovsky I, et al. The FHIT gene at 3p14.2 is abnormal in breast carcinomas. Cancer Res, 1996,56(14):3173～9.
  • 9[9]Matthews CP, Shera K, Kiviat N, et al. Expression of truncated FHIT transcripts in cervical cancers and in normal human cells. Oncogene, 2001,20(34):4665～75
  • 10[10]Sozzi G, Pastorino U, Moiraghi L, et al. Loss of FHIT function in lung cancer and preinvasive bronchial lesions. Cancer Res, 1998,58:5032～7.

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实用肿瘤学杂志
2009年 第2期

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