复方丹参滴丸对老年单纯收缩期高血压血管内皮依赖性舒张功能的影响

Effect of Fufangdanshen Pill on Endotheliam-Dependent Dilation Function in Patients with Elderly Isolated Systolic Hypertension

目的:评价复方丹参滴丸对老年单纯收缩期高血压病人血管内皮依赖性舒张功能的影响。方法:单纯收缩期高血压(ISH)66例,年龄60～80岁,随机分为A、B两组,其中33例为A组,在抗高血压药非洛地平缓释片的基础上,联合应用复方丹参滴丸;B组33列,单用非洛地平缓释片内服,两组均连续用药12周,治疗前后对相关指标进行检测与对比观察,并采用高分辨超声测定患者用药前后的反应性充血和含服硝酸甘油后肱动脉内径的变化。结果:与治疗前比较,两组的收缩压(SBP)与舒张压(DBP)均显著下降(P<0.01与P<0.05),组间比较,SBP、DBP的下降两组差异无显著性(P>0.05)。血清总胆固醇(TC)及低密度脂蛋白胆固醇(LDL-C)A组治疗后明显下降(P<0.01),而B组TC、LDL-C下降不明显(P>0.05)。血管内皮依赖性舒张功能指标值(FMD)在A组用药前后比较差异非常显著(P<0.01),B组差异亦有显著性(P<0.05),组间比较A组FMD改善程度明显优于B组(P<0.01)。两组的非依赖性血管内皮舒张功能(NID)用药前后均无显著变化(P>0.05)。治疗期间未见复方丹参滴丸严重不良反应。结论:ISH患者血管内皮依赖性舒张功能受损,复方丹参滴丸改善其血管内皮功能,有益于ISH患者的治疗。

Objective:To assess the effect of Fufang Danshen pill(FFDSP)on endotheliam-dependent dilation function(EDDF)in patients with elderly isolated systolic hypertension(ISH).Methods:Sixty-six patients of ISH were randomized to receive felodipine(group B)or felodipine combined with FFDSP(group A)for 12weeks.The baseline of biachial angiobore and changes of it at respone to nitroglycerin and reactive hyperaemia were assessed by high-resolution ultrasonography before and after treatment.Results:SBP and DBP were significantly reduced in both groups after 12 weeks treatment compared to basiline level(P<0.01 or P<0.05,respectively).The magnitude of reduction in SBP and DBP were similar in two groups(P>0.05,all).The levels of TC、LDL-C decreased significantly(P<0.01) after FFDSP treatment 12 weeks.While in group B,the levels of TC、LDL-C were not significantly decreased(P>0.05 all)after treatment.EDDF parameter(FMD) was improved(P<0.01) in group A,it was better(P<0.01) than that of group B.However,there were no significantly change of vasodilation in response to nitroglycerin(NID) in both groups(P>0.05 all).No severs adverse effect was found in treating with FFDSP.Conclusion:EDDF was impaired in ISH patients,and FFDSP may improve impaired EDDF which was speculated beneficial to ISH patients.