摘要
Eight novel heterocycle-substituted dihydropyrazole derivatives were synthesized and characterized by ESI-MS, ^1H NMR and ^13C NMR. All of the compounds have been screened for their antibacterial potential in vitro against Bacillus subtilis, Staphylococcus aureus, Escherichia coli and Pseudomonas aeruginosa. The results show that compounds 9b, 9g and 9h displayed significant activity with MIC values in the range of 0.39-1.562 μlmL against B. subtilis.
Eight novel heterocycle-substituted dihydropyrazole derivatives were synthesized and characterized by ESI-MS, ^1H NMR and ^13C NMR. All of the compounds have been screened for their antibacterial potential in vitro against Bacillus subtilis, Staphylococcus aureus, Escherichia coli and Pseudomonas aeruginosa. The results show that compounds 9b, 9g and 9h displayed significant activity with MIC values in the range of 0.39-1.562 μlmL against B. subtilis.
基金
the opening foundation of the Key Laboratory of Green Pesticide and Agricultural Bioengineering,Ministry of Education,Guizhou University,(No.2008GDGP0105)
supported by the Young College Teachers Research Projects of Anhui Province(No.2008JQ1030)
the Young College Teachers Research Projects of Anhui University of Technology(No.QZ200809).
