摘要
目的探讨异位性皮炎患者皮损内白细胞介素4(Interleukin 4,IL-4)的表达及其临床意义。方法采用荧光定量聚合酶链反应法测定15例异位性皮炎患者皮损内及15例正常对照者皮肤内IL-4mRNA的定量表达,采用湿疹面积及严重度指数(EASI)评分评估患者病情,分析异位性皮炎患者皮损内IL-4mRNA的定量表达与EASI评分相关性。结果异位性皮炎患者皮损内IL-4mRNA的表达明显高于对照组皮肤内的表达(t=9.02,P<0.0001)EASI评分呈显著的正相关(r=0.79630,P=0.0004)。结论异位性皮炎患者皮损内IL-4mRNA的过度表达可能与异位性皮炎患者的发病有关。
Objective To investigate the expression and significance of interleutin 4 （IL-4） in patients with atopic dermatitis. Methods Fifteen adult patients with atropic dermatitis and 15 healthy controls were sequentially enrolled in this study. The production of IL-4 mRNA was measured by fluorescent quantitative polymerase chain reaction.（PCR） The patients＇s condition were measured by eczema area and severity index （EASI）. The correlation between expresion of IL-4 mRNA and EASI was analyzed. Results Expression of IL-4 mRNA in atopic dermatitis was significantly higher than that in healthy controls （t=9.02,P〈0.0001）. Significant posivtive correlation of expression of IL-4 mRNA in in atropic dermatitis with EASI scores （r=0.79630,P=0.0004） was noticed. Conclusion These findings suggest an important role of IL-4 in the occurrence of patients with atopic dermatitis.
出处
《中国热带医学》
CAS
2009年第5期832-833,共2页
China Tropical Medicine
