鼻咽癌放疗前后血清VEGF和bFGF的变化

Variations of serum concentrations of VEGF and bFGF in patients with nasopharyngeal carcinoma before and after radiotherapy

目的探讨血清血管内皮生长因子(VEGF)和碱性纤维母细胞生长因子(bFGF)水平与鼻咽癌的关系及其临床意义。方法采用酶联免疫吸附法(ELISA)检测37例健康献血员和48例鼻咽癌患者的血清VEGF和bFGF水平,其中33例放射治疗结束以后复查血清VEGF和bFGF。结果初诊鼻咽癌患者血清VEGF和bFGF水平分别为(175.2±26.9)pg/ml和(87.2±16.9)pg/ml,而正常对照组则分别为(102.8±12.7)pg/ml和(60.8±8.3)pg/ml,均有统计学差异(P<0.01)。鼻咽癌患者血清VEGF和bFGF水平与鼻咽癌病理类型无显著相关性(P>0.05)。放疗后肿瘤消退的患者,血清VEGF和bFGF水平显著下降,与放疗前比较差异均有显著性(P<0.05),肿瘤复发时血清VEGF和bFGF水平则又复上升(P<0.05)。结论鼻咽癌患者肿瘤负荷与血清VEGF和bFGF水平密切相关,VEGF和bFGF测定可作为鼻咽癌放疗后疗效判断和临床随访的重要指标。

Objective To investigate the changes of serum concentrations of vascular endothelial growth factor （VEGF） and fibroblast growth factor-basic （bFGF） in patients with nasopharyngeal carcinoma （NPC）. Methods The serum concentrations of VEGF and bFGF were determined in 35 healthy adults and 42 patients with NPC by enzyme immunoassay （ELISA）.AU of the patients accepted radiotherapy and the serum coricentration of VEGF and bFGF were examined in 33 patients after radiotherapy. Results The serum concentrations of VEGF and bFGF in the patients with NPC was significantly higher than that of the healthy adults （P〈0.01）（VEGF： 175.2±26.9pg/ml VS 102.8±12.7pg/ml; bFGF： 87.2±16.9pg/ml VS 60.8±8.3pg/ml） . 0013.There was no correlation of VEGF and bFGF values with the types of pathology （P〉0.05）.The serum concentrations of VEGF and bFGF decreased significantly after radiotherapy（P〈0.05）.The serum concentrations of VEGF and bFGF increased significantly in the patients with relapse NPC （P〈0.05）. Conclusion There was significant correlation between the levels of serum VEGF and bFGF with cancer load of the patients with NPC. The serum concentrations of VEGF and bFGF might be a important index in the therapeutic evaluation and follow-up of NPC after radiotherapy.