5-氟尿嘧啶治疗尖锐湿疣复发的临床观察

Effect of local injection and outside application of 5-Fluorouracil on recurrent condyloma acuminatum

目的观察5-氟尿嘧啶(5-Fu)局部注射联合外用治疗尖锐湿疣的临床疗效及其对复发的影响。方法86例尖锐湿疣患者随机分成两组,均先采用CO2激光切除疣体。治疗组46例,待创面完全愈合后,于局部皮下注射5-Fu+2%利多卡因注射液(按体积1:2)约0.5ml^1.0ml,2周1次,共4次,同时外用其混合液涂搽患外3日一次,共20次。对照组:采用а-干扰素300万u肌注,2日1次,10次1个疗程,之后观察2周,再重复治疗1个疗程。疗程结束后随访6个月,记录两组复发率并进行统计学处理。结果治疗组复发率为10.87%,对照组为27.50%,两组差异有显著性(χ2=3.98,P<0.05)。结论5-Fu局部注射联合外用治疗尖锐湿疣疗效确切,复发率低,且经济实用,不失为治疗尖锐湿疣,预防其复发的有效方法之一。

Objective To observe the effect of local injection and outside application of 5-Fluorouracil （5-Fu） on recurrent condyloma aeuminatum（ CA ）. Methods There 86 CA cases were divided into the treatment group（46 cases） and control group（40 cases）. All patients were treated with CO2 laser at first,and then they were given with re-erymycetin tables 0.15g twice per day for seven days. The treatment group were given 5-Fu and 2% lidocaine by injection once every two weeks for four times. Meanwhile outside application of mixed solution was also used on patients in treatment group. The control group were treated with a-interfen （3 000 000 unit by intramuscular injection once every two days for ten times. Two week later patients in control group were retreated . Six months later the results were analyzed. Results The recurrent rate were 10.87% in treatment group,and 27.5% in the control group,showing significant difference （X^2=3.98% ,P〈0.05）. Conclusion Local infection of 5-Fu plus outside application of mixed solution is effective in treatment of CA with low recurrence and economy.