三联疗法根除幽门螺杆菌的临床观察

目的观察雷尼替丁、左氧氟沙星及呋喃唑酮三联2w疗法根除幽门螺杆菌(Hp)的疗效和安全性。方法将100例符合条件的Hp阳性的消化性溃疡患者随机分为两组,每组各50例。治疗组采用雷尼替丁(150mg,2次/d),左氧氟沙星(200mg,2次/d)加呋喃唑酮(100mg,2次/d),治疗14d;对照组采用奥美拉唑(20mg,2次/d)+阿莫西林(1.0g,2次/d)+甲硝唑(400mg,2次/d)治疗,疗程2w;观察、记录治疗过程中发生的各种不良反应,检测和统计治疗价格。结果治疗组和对照组Hp根除率和溃疡愈合率分别为76%、90%和68%、82%。差异无统计学意义(P>0.05)。治疗组与对照组每例的费用分别为62元和190元。结论雷尼替丁、左氧氟沙星及呋喃唑酮三联2w疗法根除幽门螺杆菌(Hp)是临床上理想的治疗方案,值得临床推广使用。

Objective To study the effect and safety of two-week combination therapy of ranitidine, levofloxacin and furazolidone in the eradication of Helicobacter pylori （H. pylori）.Methods 100 patients with peptic ulcer and positive H. pylori were randomly allocated into 2 groups each consisted of 50 patients. The treatment group received ranitidine 150mg＋levofloxacin 200mg＋furazolidone 100 mg/twice daily for two weeks; The patients in the the control group omeprazole 20mg＋amoxicillin l1＋metronidazole 400 mg/twice daily each, for two weeks; Side effects were observed and recorded during the reatment; endoscopy was performed and H. pylori was detected.Results Tire eradication rate and healing rate of H. pylori were 76%-90% in the treatment group and 68%-82% in the control group. There were no difference in H. pylori eradication rates and healing rates of peptic ulcer between the treatment group and control group （P〉0.05）;each patient in the treatment group and the control group pay fou 62 yuan and 190 yuan. Conclusion The combination therapy of ranitidine, levofloxacin and furazolidone in the eradication of Helicobacter pylori （H. pylori） is a perfect therapeutic schemes. It is worthy applying in clinic.