慢性心衰病人的运动能力与骨骼肌改变

Change of Skeletal Muscle and the Inability to Perform for Patients of Chronic Heart Failure

通过文献综述法,对慢性心衰中存在的骨骼肌病变进行总结。结果表明:慢性心衰病人的主要症状下肢疲劳,运动能力下降,不仅是心功能下降导致的,同时还有骨骼肌本身的病变。心衰病人的预后与心功能指标的相关性较差,而与运动能力下降的程度相关性较高。改善病人的心输出量并不能很快提高心衰病人的运动能力,说明除了心功能的改变,也存在着骨骼肌本身的改变。建议:重视心衰病人的骨骼肌病变,进行合理的运动康复,设计以骨骼肌为靶点的药物将有助于提高心衰病人的生活质量,改善心功能。

Chronic heart failure patientsinitial complaint is often the inability to perform desired activites due to dyspnea or fatigue. The generation of symptoms that limit exercise cannot be explained entirely by the central haemodynamic status,in fact,pronounced structural and functional abnor- malities in skeletal muscle have been observed in patients with chronic heart failure. Proper exercise training and new drugs targeting at skeletal muscle would prove the exercise ability and life quality of the chronic heart failure patients.