压电蛋白芯片分析仪的研制

Study of Piezoelectric Analyzer of Protein Chip

目的:研制一种可以快速检测血液样品中的乙肝表面抗原、HIV抗体和人禽流感H5N1抗体的便携式分析设备。方法:系统以STC89C52微处理器为控制核心,采用嵌入式系统技术,通过对石英晶体阵列谐振频率的检测处理,利用石英晶体微天平对表面质量负载的高度敏感性及抗体和其对应抗原间的特异识别进行快速检测。结果:该压电蛋白芯片分析仪整机灵敏度高、特异性好、便于携带,可实现多参数同步检测。结论:压电蛋白分析仪的研制突破了传统的体外诊断试剂方法,达到了临床使用要求。

Objective To develop a portable analyzer which can rapidly detect antigen of type B hepatitis, antibody of HIV and H5N1 in blood samples. Mothods The micro-processor of STC89C52 was adopted as the controlling core in the system. Based on an embedded technology, the analyzer can rapidly detect the antigen of type B hepatitis, antibody of HIV and H5N1 by processing the synchronic frequency of quartz crystal micro-array and by sensitivity of quality on the surface of quartz crystal with special identification between antibody and antigen. Results The system has the advantages of high sensitivity, better sample-specific characteristics, convenient portability and multi-parameter simultaneous detection. The piezoelectric analyzer exceeds the traditional reagent method and serves for institution of scientific research and hospital widely.