摘要
目的分析肾脏疾病患者不同类型的病理改变与足细胞数量的关系,研究二者之间的相关性,寻找足细胞在判断疗效与预后方面的积极意义。方法对277例肾穿病人肾组织进行常规病理染色及免疫荧光、电镜检查进行病理分型,同时进行肾脏足细胞计数,对二者进行相关性分析,了解肾小球足细胞数量与肾脏病病理分型及预后是否相关。结果局灶节段性肾小球肾炎(FSGS)、膜性肾病(MN)与糖尿病肾病(DN)和足细胞病变有绝对关系;肾小球足细胞数目与尿蛋白多少呈负相关;尿蛋白是临床判断肾脏病活动与否的依据之一。结论故肾小球足细胞可以作为判断临床肾病活动的依据之一。
Objective After the rountine kidney tissue pathological dying, immunization fluoroscope electronical examination for the 277 kidney disease sufferers and pathological categorzing and counting of podocyte in kidney.Method the relationship beween pathological change and podocyte number was analyzed to search for podocyte＇s positive role in judging treatment effect and prognosis. Result an abosolute relationship exists among FSGS, MN, DN and podocyte pathological change.The greater podocyte number of glomerulus, the less of the urinary protein. Clinically, urinary protein, is one of the determing factors for kidney diseases assumption. Conclusion podocyte of glomerulus can be considered as one of the determing factors for kidney diseases assumption.
出处
《医学信息》
2009年第5期717-719,共3页
Journal of Medical Information
