针刺外关穴与外关配伍非穴的fMRI脑功能成像比较

Comparison of fMRI cerebral functional imaging between needling Waiguan (SJ5) and combined SJ5 and sham point

[目的]观察针刺健康志愿者右侧外关穴和外关穴配伍非穴时不同脑区的激活。[方法]16例健康志愿者,随机分为外关穴组和外关穴配伍非穴组,分别针刺右侧外关穴和外关穴配伍非穴;同时,运用GE1.5T超导核磁共振系统完成脑部fMRI扫描,所得数据采用感兴趣区(ROI)法进行处理和分析。[结果]针刺外关穴和外关穴配伍非穴,对双侧额叶、顶叶、颞叶、枕叶、海马、扣带回、基底节、桥脑、小脑等脑区都有不同程度的激活,其激活点数和激活强度都没有显著差异,但针刺外关穴对右侧小脑的激活几率高于针刺外关穴配伍非穴(P<0.05),并有趋势表明,针刺外关穴还能较为集中地激活左侧顶叶、右侧额叶、颞叶。[结论]fMRI脑功能成像研究表明,外关穴与非穴的配伍关系,不是简单的1+0=1的对应关系。

[Objective] To observe the cerebral activating effects of needling Waiguan （SJS） and the combined SJ5 and sham point in healthy volunteers.[nethods] Sixteen healthy volunteers were randomly divided into SJ5 group and SJ5 with sham point group. They received needling in different points on the right hand respectfully. Super nuclear magnetic resonance （1.ST, GE Co.） was used to scan the brain and the obtained experimental data of the regional brain were processed and analyzed by method of Region of Interest （ROI）. [Results] Both needling in SJ5 and combined SJ5 and sham point could activate bilateral parietal, frontal, occipital and temporal lobes, basal ganglia, cingulate gyri, hippocampus, cerebellum, and pons in different degree. Compared with needling combined SJ5 and a sham point, Acupuncture in SJ5 could specially activate the right cerebellum （P〈0.05）, and had a tendency to show that needling SJ5 could also active the left parietal lobe, right frontal and temporal lobes more intensively. [Conclusion] Based on the analysis of fMRI cerebral imaging, the compatible relationship of SJ5 and the combined SJ5 and sham point is not simply like that of 1 ＋0= 1.