硫普罗宁治疗化疗药物性肝损伤临床观察

Effect of tiopronin on liver injury caused by chemotherapy

目的:观察硫普罗宁治疗化疗药物所致轻度肝损伤的疗效和安全性。方法:将化疗后有轻度肝损伤的60例恶性肿瘤患者随机分为治疗组和对照组各30例,对照组以肌苷0.6g,维生素C2.0g,维生素B60.2g加5%葡萄糖溶液中静脉滴注,每天1次,连续治疗7天;治疗组除上述治疗外,另以硫普罗宁0.2g加5%葡萄糖液中静脉滴注,每天1次,连续治疗7天。同时分别监测肝功能指标谷丙转氨酶(ALT)、谷草转氨酶(AST)、总蛋白(TP)、总胆红素(TBi)、总胆汁酸(TBA)等,并进行比较。结果:治疗组较对照组在肝功能复常方面显示良好的治疗效应,使转氨酶明显下降,治疗组与对照组有效率比较差异有显著性(P<0.01)。结论:短期临床研究资料提示硫普罗宁治疗化疗药物所致轻度肝损伤,可明显改善肝脏功能,不良反应少,疗效显著,保持化疗连续性。

Objective：To observe the effect of tiopronin on hver injury caused by chemotherapy. Methods：60 cancer patients suffered from slight liver injury after chemotherapy were randomly divided into treatment group and control group,each group 30 patients. The control group was used titamin C ,titamin B6, inosine. The treatment group was used tiopronin in addition to the treatment abovementioned.ALT, AST, TP,TBi and TBA were monitored. Results：The treatment group had significantly better effective ratio to recover the level of ALT compare with control group （P〈0.01）.Conclusion：Tiopronin has significantly effect on recovering from hepatic injury after chemotherapy in the patients with cancer.