1Park H,Li Z X,Yang X O et al.A distinct lingage of CD4^+ T cells regulates tissue inflammation by producing interleukin 17[J].Nat Immunol , 2005;6(11 ):1133-1141.
2Harrington L E, Hatton R D,mangan P R et al.Interleukin 17-producing CD4^+ effector T cells develop via a lineage distinct from the T helper type 1 and 2 lineages[J].Nat Immunol,2005 ;6( 11 ):1123-1132.
3Eberl G,and Littman D R.Thymic origin of intestinal alpha-beta T cells revaled by fate mapping of RORγ 1^+ cells[J] .Science,2004;305,248-251.
4Huang Z,Xie H,Wang R et al.Retinoid-related orphan receptor gamma tis a potential therapeutic target for controlling inflammatory antoimmunity [J].Expert Opin Ther Targels, 2007 ; 11 (6) : 737-743.
5Ivaylo II,McKenzie B S,Zhou L et al.The orphan nuclear receptor RORγ t directs the diferentiation program of proinflammatory IL-17^+ T helper cells[J].Cell,2006; 126(6) : 1121-1133.
6Yang X O,Pappu B P,Nurieva R et al.T Helper 17 Lineage Differentiation Is Programmed by Orphan Nuclear Receptors RORalpha and RORgamma[ J]. Immunity,2008 ; 28( 1 ) : 29-39.
7Bettelli E,Carrier Y,Gao W et al.Reciprocal developmental pathways for the generation of pathogenic effector or TH17 and regulatory T cells[J]. Nature, 2006 ; 441 (7090) : 235-238.
8Mucida D, Park Y, Kim Get al. Reciprocal Th17 and regulatory T Cell differentiation mediated by retinoic acid [ J ]. Science, 2007 ; 317 ( 5835 ) : 256-260.
9Fantini M C,Rizzo A,Fina D et al.IL-21 regulats experimental colitis by modulating the halance between Treg and Th17 cells[J].Eur J Immunol,2007 ; 37 ( 11 ) : 3155-3163.
10Chen Z, O' Shea J Jet al. Th17 ceils: a new fate for differentiating helper T cells[J]. Immunol Res,2008;41 (2) :87-102.
3WHO. World Malaria Report 2013[R]. Geneva: WHO, 2013.
4Murray C J, Rosenfeld LC, Lira SS, et al. Global malaria mor- tality between 1980 and 2010: a systematic analysis[J]. Lancet, 2012, 379(9814): 413-431.
5Vogel G. The forgotten malaria [J]. Science, 2013, 342(6159): 684-687.
6Braga EM, Carvalho LH, Fontes CJ, et d. Low cellular response in vitro among subjects with long-term exposure to malaria trans- mission in Brazilian endemic area [J]. Am J Trop Med Hyg, 2002, 66(3): 299-303.
7Goonewardene R, Carter R, Gamage CP, et al. Human T cells proliferative responses to Plasmodium vivax antigens: evidence of immunosuppression following prolonged exposure to endemic malaria[J]. Eur J Immunol, 1990, 20(6): 1387-1391.
8Orengo JM, Wong KA, Ocafia-Morgner C, et 01. Plasmodium yoelii soluble factor inhibits the phenotypic maturation of dendritic cells [J]. Malar J, 2008, 15(7): 254.
9Perry JA, Rush A, Wilson R J, et ol. Dendritic ceils from ma- laria infected mice are fully functional APC [J]. J Immunol, 2004, 172(5): 475-482.
10Leisewitz AL, Roekett KA, Gumet B, et ol. Response of the splenic dendritic cell population to malaria infection [J]. Infect Immun, 2004, 72(7): 4233-4239.
