萸连巴布剂体外释放和透皮行为的研究

Study on vitro release and transdermal behaviors of Yulian cataplasm

目的:考察萸连巴布膏的体外释放和透皮行为和规律。方法:试验采用改良Franz扩散装置,用HPLC法使用1种流动相测定接收液中吴茱萸碱、吴茱萸次碱、巴马汀、小檗碱4种指标成分的含量。结果:吴茱萸碱、吴茱萸次碱、巴马汀、小檗碱释放速率分别为0.0239,0.0156,0.0725,0.8191 mg.cm-2.h-1/2;透皮速率分别为1.256,1.0302,2.8029,20.919μg.cm-2.h-1。结论:萸连巴布剂的体外释放符合Higuchi方程,透皮行为为零级过程。

Objective： To investigate the regularity of Yulian Cataplasm in vitro release and transdermal behaviors. Method： Improved Franz diffusion devices was used with four index ingredients as evodiamine, ruraecarpine, palmatine and berberine that were determined by HPLC in one mobile phase. Result： The release rates of evodiamine, rutaecarpine, palmatine and berberine were 0. 023 9, 0. 015 6, 0. 072 5, 0. 819 1 mg . cm^-2 . h^-1/2 ,respectivley. The transdermal rates of evodiamine, rutaecarpine, palmatine and berberine were 1. 256, 1. 030 2, 2. 802 9, 20. 919μg.cm^-2 . h^-1, respectively. Conclusion： The releasing process of all index is in accordance with Higuchi equation and the transdermal proccess is in accordance with zero-level equation.