肿瘤组织中的CYP1B1及其抑制剂的抗肿瘤活性

Tumor Cytochrome P450 1B1 and Antitumor Activities of Its Inhibitors

综述细胞色素P450酶(CYP)1B1在肿瘤组织中的表达、在肿瘤的发生发展和诊断与干预中的作用以及其抑制剂的研发和抗肿瘤活性。CYP1B1在正常组织中低表达,而在许多肿瘤组织中则特异性高表达,可激活和代谢产生致癌物质,并可致多种抗癌药物代谢失活而使肿瘤耐药,因此它既可用于早期癌症的诊断,又可作为理想的抗肿瘤作用靶点而用于药物研发。

The tumor-specific expression, function in tumor development and role in tumor diagnosis and interference of CYP1 B1 and the development and antitumor activities of its inhibitors were reviewed. CYP1 B1, which is expressed highly in many tumors but lowly in normal tissues, could induce carcinogens to be produced via activation and metabolism and cause metabolic inactivation of many anticancer drugs to lead to tumor drug-resistance. It may play the important roles in tumor diagnosis and drug development as a promising antitumor target.