胺碘酮转复阵发心房颤动的疗效观察

Comparison of the effect of amiodaron on cardioversion of paroxysmal attuak fibrillation

目的：研究胺碘酮转复阵发心房颤动的疗效。方法：阵发心房颤动患者45例随机分为两组：胺碘酮组25例，给予胺碘酮负荷量150mg静注后，继以0．6～1．0mg／min维持点滴，依心室率情况调整胺碘酮剂量。心律平组20例，静脉给予心律平1．4～2．0mg／kg，5min内注射，继以0．28mg／min维持静点，无效者改用胺碘酮治疗。结果：胺碘酮组转复成功率为84．0％（21／25），心律平组转复成功率60．0％（12／20），且心律平组转复心律失败的部分病例使用胺碘酮仍有效；胺碘酮组平均复律时间（103±65）min短于心律平组（160±78）min。结论：胺碘酮在转复阵发心房颤动比心律平更加快速、安全、有效。

Objective ： To observe the effect of amiodaron on the cardioversion of paroxysmal auricular fibrillation （PAF）. Methods ： 45 PAF cases were radomly divide into two groups ：25 cases who accepted amiodaron 150 mg intravenous injection , and 0.6 - 1.0 mg/ min intravenous drip afterwards in amiodaron group , other 20 cases who accepted propafenone 1.4 - 2.0 mg/ kg veininjection , and 0.28 mg/min intravenous drip afterwards in propafenone group. If propafenone was not effective , the cases in propafenone group were given amidoaron. Results： The successful reversion rate was 84.0% （21/25） in amidoaron group while 60.0% （12/20） in propafenone group （P 〈 0.05 ） . The mean time of recovering was （103 ± 65 ） min in amidoaron group , while （160± 78） min in propafenone group （P 〈 0. 05 ）. Conclusion ： It is more rapid and effective of amidoaron on the cardioversion of paroxysmal auricular fibrillation than propafenone.