颌骨中心性腺源性肿瘤22例临床分析

A clinical study of 22 patients with central salivary gland tumors of the jaws

目的：分析颌骨中心性腺源性肿瘤的f临床特点、治疗方法以及预后相关因素，提高此类疾病的诊断水平和治疗效果。方法：收集四川大学华西口腔医院1986-2006年间收治的22例颌骨中心性腺源性肿瘤的临床及随访资料并进行分析。结果：22例颌骨中心性腺源性肿瘤，男7例，女15例；上颌骨9例，下颌骨13例。29-59岁病例占68．2％。临床表现不典型．以颌骨膨隆或肿块、疼痛、牙松动较为多见。诊断困难，病理学类型多样，恶性占绝大多数，黏液表皮样癌最为常见，占45．5％。手术是主要的治疗方式，预后与其病理学类型和临床分期密切相关。结论：术前活检是颌骨中心性腺源性肿瘤的确诊手段。手术是主要的治疗方式．手术方式主要是根治性切除，根据具体情况选择区域颈淋巴清扫术。足够边界的切除是减少肿瘤复发的关键。

PURPOSE： The aim of this study was to analyze the clinical features, treatment and factors affecting the prognosis of patients with central salivary gland tumors of the jaws. METHODS： Twenty-two patients with central salivary gland tumors of the jaws at West China Hospital of Stomatology, Sichuan University in the recent 20 years were retrospectively analyzed according to the clinical features, treatment and factors affecting the prognosis. A thorough review of clinical records was performed and the histological diagnosis was revised according to the 2005 WHO criteria. RESULTS： Most central salivary gland tumors of the jaws occurred in middle-aged females. Diagnosis was difficult because clinical manifestations were not typical as swelling of the jaws, pain and tooth mobility were common. Most of these diseases were malignant and pathological types were diverse. Mucoepidermoid carcinoma was the most common type. Surgery was the primary treatment plan. CONCLUSIONS： It can be concluded that the final diagnosis in most patients with central salivary gland tumors of the jaws is acquired by preoperative biopsy. Surgery was the primary treatment method and radical resection is the first choice for the patients. The resection of sufficient frontier could reduce the chance of recurrence to a great extent.