套扎术联合奥曲肽、奥美拉唑治疗食管静脉曲张破裂出血效果观察

Clinical efficacy of esophageal variceal ligation in combination with Octreotide and Omeprazole for esophageal variceal bleeding

目的观察食管静脉套扎术(EVL)联合奥曲肽、奥美拉唑治疗食管静脉曲张破裂出血(EVB)的近远期效果。方法将95例肝硬化急性上消化道大出血的患者随机分成两组,治疗组采用EVL联合静脉应用奥曲肽、奥美拉唑治疗;对照组静脉应用奥曲肽、奥美拉唑治疗。观察两组术后不同时段内再出血发生率和门脉高压性胃病的情况。结果治疗组在术后15天,1、3、6个月和1年内再出血发生率明显低于对照组(P均<0.05),食管静脉曲张明显改善而门脉高压性胃病未见加重。结论EVL联合静脉应用奥曲肽、奥美拉唑能有效降低EVB再出血率,减少食管静脉曲张,值得临床推广。

Objective To evaluate the short - and long - term efficacy of esophageal variceal combination with Octreotide and Omeprazole for esophageal variceal bleeding （EVB）. Methods ligation （EVL） in 95 patients with acute upper digestive tract bleeding enrolled in this study were randomly divided into two groups, the therapeutic group received EVL in combination with intravenous Octreotide and Omeprazole; and the control group was given intravenous Octreotide and Omeprazole. The re - bleeding rate and incidence of portal hypertension stomach diseases at different time points were recorded for both groups Results On day15, and 1, 3, 6 months , and 1 year after operation, the therapeutic group in re- bleeding rate was significantly lower than that in the control group （all P values 〈 0.05 ）, esophageal varices relieved and portal hypertension stomach diseases did not worsen. Esophageal Conclusion variceal ligation in combination with Octreotide and Omeprazole can effectively decrease re - bleeding rate in EVB, ameliorate esophageal varices, and should be clinically recommended.