C型利钠利尿肽在人乳牙根生理性吸收过程中的表达

Expression of C-type Natriuretic Peptide During the Stage of Physiological Root Resorption of Human Primary Teeth

目的:探讨C型利钠利尿肽(C-type natriuretic peptide,CNP)在人乳牙根生理性吸收过程中的表达及作用。方法:运用免疫组织化学方法检测人乳牙根生理性吸收过程中CNP蛋白的表达。结果:乳牙的破牙细胞、牙髓成纤维细胞及成牙本质细胞胞浆中CNP免疫组化染色阳性,且表达高于恒牙组,差异有统计学意义(P<0.05),乳牙牙周韧带成纤维细胞CNP染色亦阳性。结论:CNP在人乳牙牙根生理性吸收过程中有表达,可能对乳恒牙替换起到一定的促进作用。

Objective：To investigate the function and the expression of C-type Natriuretu Peptide（CNP） during the stage of physiological resorption of human primary teeth. Methods：CNP was observed the expression in primary teeth root and periodontal tissue by immunohistochemistry. Results：CNP positive signals were observed in odontoclast,pulp fibroblast and odontoblast in primary teeth. The expression of CNP in the study group was higher than in the control group （P〈0.05）. CNP positive signals were also observed in periodontal ligament fibroblasts in primary teeth. Conclusion：CNP expresses during the stage of the physiological root resorption and might involve in the replacement of primary and permanent teeth.