期刊文献+
任意字段
题名或关键词
题名
关键词
文摘
作者
第一作者
机构
刊名
分类号
参考文献
作者简介
基金资助
栏目信息

血管紧张素Ⅱ及其受体在肿瘤中作用的研究进展 被引量：2

Research progress on the function of angiotensin Ⅱ receptors in tumor
下载PDF
导出
摘要 血管紧张素Ⅱ作为肾素-血管紧张素系统中的主要效应分子,除了收缩血管,调节血压功能外,还参与肿瘤的发生发展、炎症反应以及血管形成转移,并且发挥重要作用。该文就血管紧张素Ⅱ及其受体在肿瘤中的表达及信号传通路研究进展做一综述。 Angiotensin Ⅱ is a biologically activated peptide of the rennin-angiotensin system （RAS）. Beside constracting vascular and regulating blood pressure, Ang Ⅱ plays an important role in the development of tumor, inflammation and angiogenesis. The expression and major intracellular signaling pathways of Ang Ⅱ and Ang Ⅱ receptors in tumor are reviewed.
作者 张艳春 周金培 吴晓明
机构地区 中国药科大学药物化学教研室
出处 《中国药理学通报》 CAS CSCD 北大核心 2009年第4期441-443,共3页 Chinese Pharmacological Bulletin
关键词 血管紧张素 血管紧张素Ⅱ受体 抗肿瘤 angiotensin angiotensin Ⅱreceptor antitumor
分类号 R-05 [医药卫生] R392.11 [医药卫生—免疫学]
  • 相关文献

参考文献18

  • 1Gendron L, Payet M E, Gallo-Payet N. The angiotensin type 2 receptor of angiotensin Ⅱ and neuronal differentiation : From observations to mechanisms [ J ]. J Mol Endocrinol,2003,31 : 359 - 72.
  • 2Herr D, Rodewald M, Fraser H M,et al. Regulation of endothelial proliferation by the renin-angiotensin-system in human umbilical vein endothelial cells[ J]. Reproduction, 2008,136( 1 ) : 125 - 30.
  • 3Efrati S, Berman S, Goldfinger N, et al. Enhanced angiotensin Ⅱ production by renal mesangium is responsible for apoptosis/proliferation of endothelial and epithelial cells in a model of malignant hypertension [ J ]. J Hypertens, 2007,25 (5) : 1041 - 52.
  • 4Kobayashi S, Berisha B, Amselgruber W M,et al. Production and localisation of angiotensin Ⅱ in the bovine early corpus luteum : a possible interaction with luteal angiogenic factors and prostaglandin F2 alpha[ J]. J Endocrinol,2001,170(2 ) :369 - 80.
  • 5Herra D, Rodewald M, Fraser H M, et al. Potential role of Renin- Angiotensin-system for tumor angiogenesis in receptor negative breast cancer [ J ]. Gynecol Oncol,2008,109 ( 3 ) :418 - 25.
  • 6Chen X, Wang J, Zhou F,et al. STAT proteins mediate angiotensin Ⅱ -induced production of TIMP-1 in human proximal tubular epithelial cells [ J ]. Kidney lnt,2003,64 ( 2 ) :459 - 67.
  • 7Giatromanolaki A, Sivridis E, Fiska A, Koukourakis M I. Hypoxiainducible factor-2 alpha ( HIF-2 alpha) induces angiogenesis in breast carcinomas [ J ]. Appl Immunohistochem Mol Morphol, 2006,14( 1 ) :78 -82.
  • 8陈雪松,赵艳滨,蔡莉,隋广杰.血管紧张素Ⅱ受体、p53和Survivin在乳腺癌中的表达及相关性研究[J].现代肿瘤医学,2008,16(2):204-207. 被引量：6
  • 9Fujimoto Y, Sasaki T, Tsuchida A, Chayama K. Angiotensin Ⅱ type 1 receptor expression in human pancreatic cancer and growth inhibition by angiotensin Ⅱ type 1 receptor antagonist [ J ]. FEBS Lett,2001,495 ( 3 ) : 197 - 200.
  • 10Anandanadesan R, Gong Q, Chipisyna G, et al. Angiotensin Ⅱ induces vascular endothelial growth factor in pancreatic cancer cells through an angiotensin Ⅱ type 1 receptor and ERK1/2 signaling [ J]. J Gastrointest Surg,2008,12 ( 1 ) :57 - 66.

二级参考文献14

  • 1Koh W.Angiotenensin 1-converting enzymc(ACE)genepolymorphismad breast cancer risk among Chinese women in Singapore [J].Cancer Res,2003,63:573-578.
  • 2Suganuma T. Functional expression of the angiotensin Ⅱ type 1 receptor in human ovarian carcinoma cells and its blockade therapy resulting in suppression of tumor invasion, angiogenesis, and peritoneal dissemination[J]. Clin Cancer Res, 2005, 11 : 2686-2694.
  • 3Uemura H. Angiotensin Ⅱ receptor blocker shows antiproliferative activity in prostate cancer cells: a possibility of tyrosine knase inhibitor of growth factor [ J ]. Mol Cancer Ther, 2003,2 : 1139-1147.
  • 4Takeda H, Kondo S. Differences between squamous cell carcinoma and keratoacanthoma in angiotensin type - 1 receptor expression [J]. Am J Pathol,2001, 158:1633-1637.
  • 5Kikkawa F. Activation of invasiveness of cervical carcinoma cells by angiotensin Ⅱ[J]. Am J Obstet Gynecol,2004, 190:1258-1263.
  • 6De Paepe B. Growth stimulatory angiotensin Ⅱ type - 1 receptor is upregulated in breast hyperplasia and in situ carcinoma but not in invasive carcinoma[J]. Histochem Cell Biol, 2001, 116 : 247-254.
  • 7Dinh D. Identification, distribution, and expression of angiotensin Ⅱ receptors in the normal human prostate and benign prostatic hyperplasia[ J ]. Endocrinology, 2001,142 : 1349-1356.
  • 8De Paepe B. Increased angiotensin Ⅱ type -2 receptor density in hyperplasia, DCIS and invasive carcinoma of the breast is paralleled with increased iNOS expression [ J ]. Histochem Cell Biol, 2002, 117:13-19.
  • 9Lu CD, Altieri DC, Tanigawa N. Expression of a novel antiapoptosis gene, survivin, correlated with tumor cell apoptosis and p53 accumulation in gastric carcinomas [ J ]. Cancer Res, 1998,58 : 1808-1812.
  • 10Kawasaki H, Alitieri DC, Lu CD, et al. Inhibition of apoptosis by survivin predict shorter survival rates in colorectal cancer[ J ]. Cancer Res, 1998,58:5071-5074.

共引文献8

同被引文献66

  • 1Miyashita Y,Saiki A,Endo K,et al.Effects of olmesartan,an angio-tensin Ⅱ receptor blocker,and amlodipine,a calcium channel blocker,on Cardio-Ankle Vascular Index (CAVI) in type 2 diabetic patients with hypertension[J].J Atheroscler Thromb,2009,16 (5):621 -626.
  • 2Vijan SG.Angiotensin-converting enzyme inhibitors (ACEIs),not angiotensin receptor blockers (ARBs),are preferred and effective mode of therapy in high cardiovascular risk patients[J].J Indian Med Assoc,2009,107(3):178-182.
  • 3Robles NR,Romero B,Fernandez-Carbonero E,et al.Angiotensinconverting enzyme inhibitors versus angiotensin receptor blockers for diabetic nephropathy:a retrospective comparison[J].J Rerun Angiotensin Aldosterone Syst,2009,10(4):195-200.
  • 4Muller DN,Luft FC.Direct renin inhibition with aliskiren in hypertension and target organ damage[J].Clin J Am Soc Nephrol,2006,1 (2):22l-228.
  • 5Tomaschitz A,Pilz S,Ritz E,et al.Independent association between 1,25-dihydroxyvitamin D,25-hydroxyvitamin D and the renin-angiotensin gystem The Ludwigshafen Risk and Cardiovascular Health (LURIC) study[J].Clin Chim Acta,2010,411(17-18):1354-1360.
  • 6Forman JP,Williams JS,Fisher ND.Plasma 25-hydroxyvitamin D and regulation of the renin-angiotensin system in humans[J].Hypertension,2010,55 (5):1283-1288.
  • 7Zhou C,Lu F,Cao K,et al.Calcium-independent and 1,25 (OH)2 D3-dependent regulation of the renin-angiotensin system in 1 alpha-hydroxylase knockout mice[J].Kidney Int,2008,74(2):170-179.
  • 8Xiang W,Kong J,Chen S,et al.Cardiac hypertrophy in vitamin D receptor knockout mice:role of the systemic and cardiac renin-angiotensin systems[J].Am J Physiol Endocrinol Metab,2005,288 (1):125-132.
  • 9Li YC,Kong J,Wei M,et al.1,25 -Dihydroxyvitamin D3 is a negative endocrine regulator of the renin-angiotensin system[J].J Clin Invest,2002,110(2):229-238.
  • 10Yuan W,Pan W,Kong J,et al.1,25-Dihydroxyvitamin D3 Suppresses rennin gene transcription by blocking the activity of the cyclic AMP response element in the renin gene promoter[J].J Biol Chem,2007,282(41):29821-29830.

引证文献2

二级引证文献7

中国药理学通报
2009年 第4期

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部