特发性颞叶癫痫的MRI海马T_2弛豫时间测量

Measurement of hippocampal T_2 relaxation time on MRI in idiopathic temporal lobe epilepsy

目的:探讨海马T2弛豫时间(HCT2)在特发性颞叶癫痫(TLE)评价中的价值,并为后续的TLE病例HCT2测量与手术预后相关研究提供基础数据。方法:对36例全面性癫痫(GEP)、23例非颞叶部分性癫痫(NTPE)、26例TLE以及60例正常对照者(CL)进行HCT2测量,并分析其差异。结果:TLE组高侧平均HCT2较CL组增高7.5518ms,较GEP组及NTPE组增高4.1639ms和3.7293ms。TLE组低侧及GEP组和NTPE组低侧、高侧较CL组相应侧别分别增高2.7547ms、3.1347ms、3.2829ms、3.4669ms和3.9016ms。TLE组平均HCT2低/高比率较CL组、GEP组、NTPE组分别降低0.0482、0.0456和0.0425。结论:TLE组病灶侧HCT2明显高于CL组、GEP组及NTPE组,HCT2低/高比率降低是TLE的较特异表现。

Objective： To determine the value of hippocampal T2 relaxation time（HCT2） on MRI for the assessment of tem- poral lobe epilepsy（TLE）, and provide primary quantitative data to predict its operational prognosis by HCT2. Methods： Thirty- six cases of generalized epilepsy（GEP）, 23 non-temporal lobe partial epilepsy（NTPE）, 26 temporal lobe epilepsy（TLE） and 60 neurologically healthy people （CL） were chosen to get the HCT2 on oblique coronary MRI obtained by SE dual echo sequence, and the differences of HCT2 between different groups were analyzed. Results： The mean HCT2 of high side in TLE was 7.5518ms higher than that in CL （P=0.000）, and 4.1639ms and 3.7293ms higher than that in GEP and NTPE respectively （P=-0.000, 0.000）. The mean HCT2 of low side in TLE, low side and high side in GEP and NTPE, were 2.7547ms, 3.1347ms, 3.2829ms, 3.4669ms, 3.9016ms higher than those in CL respectively（P=0.000, 0.000, 0.000, 0.000, 0.000）. The mean HCT2 ratio of low side to high side in TLE was 0.0482, 0.0456, 0.0425 lower than those in CL, GEP and NTPE respectively（P=0.000, 0.000, 0.000）. Conclusion： HCT2 of focus side in TLE is significantly higher than those in CL, GEP and NTPE. The lower HCT2 ratio of low side to high side is relatively specific change in TLE.