肝细胞性肝癌超声造影定量参数与微血管密度的相关性研究

Correlative study between quantitative parameters of contrast-enhanced ultrasound and microvessel density in hepatocellular carcinoma

目的:探讨肝细胞性肝癌(HCC)超声造影血流灌注定量参数与肿瘤微血管密度(MVD)的相关性。方法:46例HCC患者术前行超声造影检查,利用时间-强度曲线(TIC)进行定量分析,得出肝癌及癌旁组织的达峰时间(TTP)、峰值强度(PI),与术后病理免疫组织化学染色计数的MVD进行相关性分析。结果:46例HCC与癌旁组织的TTP平均值分别为(14.24±5.11)s及(25.34±9.11)s,PI平均值分别为(43.11±10.25)dB及(20.87±8.21)dB,MVD平均值分别为52.32±18.21及21.43±8.65。HCC术前TTP与术后MVD呈负相关(r=-0.75,P<0.05),PI与MVD呈正相关(r=0.73,P<0.05)。结论:HCC超声造影定量灌注参数PI、TTP与MVD的表达有良好的相关性,可作为术前评估HCC血管生成状况的指标。

Objective： To explore the correlation between quantitation parameters of blood perfusion with contrast-enhanced ultrasound（CEUS） and mierovessel density（MVD） in hepatoeellular earcinoma（HCC）. Methods： CEUS was examined before oper- ation in 46 patients with HCC. Time-intensity curves （TIC） in 46 cases with HCC were analyzed to get the time to peak（TTP） and peak intensity （PI） of HCC and tissue around HCC. These parameters were analyzed correlatively with MVD counted with immunoeytoehemistry. Result： The mean TFP of HCC and tissue around HCC were （14.24±5.11）s and （25.34±9.11）s, the mean PI of HCC and tissue around HCC were （43.11±10.25）dB and （20.87±8.21）dB, the mean MVD of HCC and tissue around HCC were 52.32±18.21 and 21.43±8.65. The TTP before operation correlated inversely to MVD （r=-0.75, P〈0.05） of histologi- cal section after operation. The PI before operation was correlated positively to MVD （r=0.73, P〈0.05） of histological section after operation. Conclusions： The quantitative parameters of blood perfusion, TTP and PI, with calculated from CEUS was cor- related to MVD. These parameters could be a potential indicator of angiogenesis of HCC before operation.