摘要
目的:评价阿米替林配合认知疗法对抑郁症的疗效。方法:将75例抑郁症患者随机分为3组,A组(认知疗法治疗组)25例,B组(阿米替林组)25例,c组(阿米替林+认知疗法治疗组)25例,疗程6周,采用Hamilton、抑郁量表(HAMD)、抑郁自评量表(SDS)和副反应量表(TESS)在治疗前和治疗后2、4、6周末评定疗效和不良反应。结果:在治疗后4周,A、C两组减分与B组减分差异有显著性(P〈0.05);治疗6周A、B两组差异无显著性(P〉0.05),C组效果显著优于A、B两组(P〈0.01),且C组阿米替林剂量和TESS评分明显低于B组。结论:阿米替林配合认知疗法治疗抑郁症是一种经济、安全有效、依从性好的方法。
Objective: To assess the efficacy of Amitriptyline combined with cognitive - behavioral therapy(CBT) in the treatment of depressive patients. Methods: 75 depressive patients were randomized into A group (CBT group) (n = 25), B group (Amitriptyline group) (n = 25) and C group (Amitriptyline combined with CBT group)(n = 25) and studied for six weeks,HAMD,SDS and TESS were used to assess the efficacy and side effects before and two weeks, four weeks and six weeks after the treatment. Results: By the end of four weeks, there was significant difference in efficacy between A, C groups and B group (P 〈 0.05), by the end of six weeks, there was significant difference in efficacy between C group and A, B groups, there was no significant difference in efficacy between A and B group ( P 〉 0.05) ,and the doses of amitriptyline and the TESS scores of C group were significantly lower than that of B group. Conclusion: Amitriptyline combined with CBT was an economic, convenient and safe treatment in depressive patient.
出处
《中国民康医学》
2009年第8期801-802,946,共3页
Medical Journal of Chinese People’s Health
关键词
抑郁症
认知疗法
阿米替林
Depression
Cognitive - behavioral therapy
Amitriptyline