阿米替林配合认知疗法治疗抑郁症对照研究

Comparative study of amitriptyline with cognitive --behavioral therapy in the treatment of depressive patients

目的：评价阿米替林配合认知疗法对抑郁症的疗效。方法：将75例抑郁症患者随机分为3组，A组（认知疗法治疗组）25例，B组（阿米替林组）25例，c组（阿米替林＋认知疗法治疗组）25例，疗程6周，采用Hamilton、抑郁量表（HAMD）、抑郁自评量表（SDS）和副反应量表（TESS）在治疗前和治疗后2、4、6周末评定疗效和不良反应。结果：在治疗后4周，A、C两组减分与B组减分差异有显著性（P〈0．05）；治疗6周A、B两组差异无显著性（P〉0．05），C组效果显著优于A、B两组（P〈0．01），且C组阿米替林剂量和TESS评分明显低于B组。结论：阿米替林配合认知疗法治疗抑郁症是一种经济、安全有效、依从性好的方法。

Objective： To assess the efficacy of Amitriptyline combined with cognitive - behavioral therapy（CBT） in the treatment of depressive patients. Methods： 75 depressive patients were randomized into A group （CBT group） （n = 25）, B group （Amitriptyline group） （n = 25） and C group （Amitriptyline combined with CBT group）（n = 25） and studied for six weeks,HAMD,SDS and TESS were used to assess the efficacy and side effects before and two weeks, four weeks and six weeks after the treatment. Results： By the end of four weeks, there was significant difference in efficacy between A, C groups and B group （P 〈 0.05）, by the end of six weeks, there was significant difference in efficacy between C group and A, B groups, there was no significant difference in efficacy between A and B group （ P 〉 0.05） ,and the doses of amitriptyline and the TESS scores of C group were significantly lower than that of B group. Conclusion： Amitriptyline combined with CBT was an economic, convenient and safe treatment in depressive patient.