氟西汀联合阿立哌唑治疗抑郁症对照研究

A control study of fluoxetine combined with aripiprazole in depession

目的探讨氟西汀联合阿立哌唑治疗抑郁症的临床疗效和安全性。方法将81例抑郁症患者随机分为两组，研究组应用氟西汀联合阿立哌唑治疗，对照组单用氟西汀治疗，观察8w。于治疗前及治疗1w、2w、4w、6w、8w末采用汉密顿抑郁量表、临床总体印象量表评定临床疗效，副反应量表评定不良反应。结果治疗8w末研究组有效率72．5％，对照组50％，研究组显著高于对照组（Χ^2=4．168，P〈0．05）。研究组治疗第1w末汉密顿抑郁量表总分、阻滞、睡眠障碍因子分．第2w、4w末总分及阻滞、焦虑、睡眠障碍、认知障碍因子分，第6w、8w末总分及阻滞、焦虑因子分均显著低于对照组（P〈0．05或0．01）。治疗后临床总体印象量表病情严重程度、疗效总评、疗效指数因子评分均显著低于对照组（P〈0．05）。两组不良反应均轻微，副反应量表评分均无显著性差异（P〉0．05）。结论氟西汀联合阿立哌唑治疗抑郁症较单用氟西汀起效快，改善患者的阻滞、焦虑情绪、睡眠、认知障碍更为突出，提高总体疗效更为显著，且未加重不良反应，安全性高、依从性好。

Objective To explore the efficacy and safety of fluoxetine combined with aripiprazole in depession. Methods 81 depression patients were randomly divided into research group receiving fluoxetine combined with aripiprazole and control group doing fluoxetine only for 8 weeks. Clinical effieaeies were assessed with the Hamilton Depression Scale（HAMD） and the Clinical Global Impression（CGI） and adverse reactions with the Treatment Emergent Symptom Scale（TESS） before treatment and at the ends of the 1st, 2nd, 4th, 6th and 8th week treatment. Results At the end of the 8th week, effective rate was 72.5% of the research and 50% of the control group,the former significantly higher than the latter（Χ^2 =4. 168,P〈 0.05）. The HAMD total, blockage and somnipathy score at the end of the 1st week, total, blockage, anxiety,somnipathy and cognitive disorder at the ends of the 2nd and 4th and total, blockage and anxiety at the ends of the 6th and 8th were all significantly lower in the research than in the control group（P〈0.05 or 0.01）. After treatment, scores of severity degree of patient＇s condition, general comment and index of curative effect were all significantly lower in the research than in the control group（P〈0.05） . Adverse reactions of both groups were mild and there was no significant difference in the TESS scores（P 〉0.05）. Conclusion Fluoxetine combined with aripiprazole acts more rapidly than fluoxetine only in the treatment of depression, improves patients＇ blockage, anxious emotion, sleep and cognitive handicap and increases global curative effect more outstandingly, does＇nt aggravate adverse reactions, and has higher safety and better compliance.