甲状腺素对原发性甲状腺功能减退症认知功能损害的治疗效果

The effect of thyroxine treatment on the primary hypothyroidism inducing cognitive dysfunction

目的研究甲状腺素对成人原发性甲状腺功能减退症(甲减)患者认知损害的治疗效果。方法运用修订韦氏记忆量表和正背倒背任务检测26例初发成人原发性甲减患者治疗前、后及28例健康对照组的记忆功能。结果修订韦氏记忆量表检测显示,原发性甲减患者记忆商显著低于健康对照组,治疗后记忆商较治疗前明显提高(P<0.05),但仍低于健康对照组(P<0.05)。数字正背倒背任务检测,原发性甲减患者4位倒背数字任务正确率显著低于对照组(P<0.05),治疗后4位倒背数字任务正确率显著提高,与健康对照组未见明显差异(P>0.05)。结论原发性甲减患者存在记忆功能损害,甲状腺素替代治疗能够改善甲减患者的记忆功能。

Objective To investigate the effect of thyroxine treatment on the cognitive dysfunctions in adults with primary hypothyroidism. Methods 26 primary hypothyroidism patients and 28 euthyroid subjects were selected into this the research. The Wechsler Memory Scale-Chinese Revision（WMS-CR） and forward and backward digit recall task were applied to detecte the memory function of all the subjects before and after thyroxine treatment. Results The memory function of primary hypothyroidism group was lower than that of control group（ P 〈 0.05 ）, thyroxine treatment improved the memory function of primary hypothyroid patients, however, it was still lower than that of control group（ P 〈 0.05）. In the forward and backward digit recall task, the accuracy rate of primary hypothyroid patients was significantly lower than that of the control group. After treatment,there was no significant difference between that of control group（P 〉 0.05）. Conclusion The primary hypothyroidism can cause memory impairment, which can be improved by thyroxine treatment.